I01BX003341 | CUIMC Publications

A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation

Vujkovic, M., Ramdas, S., Lorenz, K. M., Guo, X., Darlay, R., Cordell, H. J., He, J., Gindin, Y., Chung, C., Myers, R. P., Schneider, C. V., Park, J., Lee, K. M., Serper, M., Carr, R. M., Kaplan, D. E., Haas, M. E., MacLean, M. T., Witschey, W. R., … Chang, K.-M. (2022). A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation. Nature Genetics, 54(6), 761–771. https://doi.org/10.1038/s41588-022-01078-z

Authors:

Marijana Vujkovic

Shweta Ramdas

Kim M Lorenz

Xiuqing Guo

Rebecca Darlay

Heather J Cordell

Jing He

Yevgeniy Gindin

Chuhan Chung

Robert P Myers

Carolin V Schneider

Joseph Park

Kyung Min Lee

Marina Serper

Rotonya M Carr

David E Kaplan

Mary E Haas

Matthew T MacLean

Walter R Witschey

Xiang Zhu

Catherine Tcheandjieu

Rachel L Kember

Henry R Kranzler

Anurag Verma

Ayush Giri

Derek M Klarin

Yan V Sun

Jie Huang

Jennifer E Huffman

Kate Townsend Creasy

Nicholas J Hand

Ching-Ti Liu

Michelle T Long

Jie Yao

Matthew Budoff

Jingyi Tan

Xiaohui Li

Henry J Lin

Yii-Der Ida Chen

Kent D Taylor

Ruey-Kang Chang

Ronald M Krauss

Silvia Vilarinho

Joseph Brancale

Jonas B Nielsen

Adam E Locke

Marcus B Jones

Niek Verweij

Aris Baras

K Rajender Reddy

Brent A Neuschwander-Tetri

Jeffrey B Schwimmer

Arun J Sanyal

Naga Chalasani

Kathleen A Ryan

Braxton D Mitchell

Dipender Gill

Andrew D Wells

Elisabetta Manduchi

Yedidya Saiman

Nadim Mahmud

Donald R Miller

Peter D Reaven

Lawrence S Phillips

Sumitra Muralidhar

Scott L DuVall

Jennifer S Lee

Themistocles L Assimes

Saiju Pyarajan

Kelly Cho

Todd L Edwards

Scott M Damrauer

Peter W Wilson

J Michael Gaziano

Christopher J O'Donnell

Amit V Khera

Struan F A Grant

Christopher D Brown

Philip S Tsao

Danish Saleheen

Luca A Lotta

Lisa Bastarache

Quentin M Anstee

Ann K Daly

James B Meigs

Jerome I Rotter

Julie A Lynch

Daniel J Rader

Benjamin F Voight

Kyong-Mi Chang

Affiliated Authors:

Danish Saleheen

Columbia Affiliation:

Vagelos College of Physicians and Surgeons
- Department of Medicine
  Seymour, Paul, and Gloria Milstein Division of Cardiology

Subjects:

Genome-Wide Association Study (MeSH)

Non-alcoholic Fatty Liver Disease (MeSH)

Grants:

R01HD056465 (NIH – Eunice Kennedy Shriver National Institute of Child Health & Human Development)

UL1TR001878 (NIH – National Center for Advancing Translational Sciences)

UL1TR002378 (NIH – National Center for Advancing Translational Sciences)

R01HL137984 (NIH – National Heart, Lung, and Blood Institute)

R01HL134853 (NIH – National Heart, Lung, and Blood Institute)

R01HL151855 (NIH – National Heart, Lung, and Blood Institute)

R01HL105756 (NIH – National Heart, Lung, and Blood Institute)

T32HL007734 (NIH – National Heart, Lung, and Blood Institute)

K08HG010155 (NIH – National Human Genome Research Institute)

U01HG011719 (NIH – National Human Genome Research Institute)

R03AI133172 (NIH – National Institute of Allergy and Infectious Diseases)

R01AI123539 (NIH – National Institute of Allergy and Infectious Diseases)

R21AI156161 (NIH – National Institute of Allergy and Infectious Diseases)

P41EB029460 (NIH – National Institute of Biomedical Imaging and Bioengineering)

R01DK127083 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)

R01DK101478 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)

UM1DK126194 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)

R01DK122586 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)

R01DK114291 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)

R21DK099716 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)

P30DK111024 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)

U01DK061738 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)

U01DK098246 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)

K08DK124577 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)

K23DK115897 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)

U01DK078616 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)

U01DK061732 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)

K23DK113252 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)

U24DK061730 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)

UM1DK078616 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)

R01AA026302 (NIH – National Institute On Alcohol Abuse and Alcoholism)

R01LM010685 (NIH – National Library of Medicine)

I01BX003341 (NIH – Veterans Affairs)

I01BX003362 (NIH – Veterans Affairs)

I01CX001737 (NIH – Veterans Affairs)

I01BX005831 (NIH – Veterans Affairs)

IK2CX001780 (NIH – Veterans Affairs)

IK2BX005759 (NIH – Veterans Affairs)

Publication Type:

Article

Unique ID:

10.1038/s41588-022-01078-z

PMID:

35654975

DOI:

10.1038/s41588-022-01078-z

Journal:

Nature Genetics

Publication Date:

2022-06-03

Data Source:

PubMed

Source Link:

View PubMed Record

View Scopus Record

View Web of Science Record

Record Created:

Thursday, January 16, 2025 - 13:25