Role of Mast Cells in Immunoregulation and Disease

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Tashi, T., Hermine, O., Castells, M., Guilarte, M., Sabato, V., Maurer, M., Panse, J., Alvarez-Twose, I., Cabral, R., Bird, R., Barete, S., Bouillet, L., Hermans, M., Van Daele, P., González-De-Olano, D., Griffiths, E. A., Jurcic, J., Dybedal, I., Damaj, G. L., … Livideanu, C. B. (2023). Elenestinib, an Investigational, Next Generation KIT D816V Inhibitor, Reduces Mast Cell Burden, Improves Symptoms, and Has a Favorable Safety Profile in Patients with Indolent Systemic Mastocytosis: Analysis of the Harbor Trial. Blood, 142(Supplement 1), 76–76. https://doi.org/10.1182/blood-2023-188904
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Gotlib, J., Castells, M., Elberink, H. O., Siebenhaar, F., Hartmann, K., Broesby-Olsen, S., George, T. I., Panse, J., Alvarez-Twose, I., Radia, D. H., Tashi, T., Bulai Livideanu, C., Sabato, V., Heaney, M., Van Daele, P., Cerquozzi, S., Dybedal, I., Reiter, A., Pongdee, T., … Maurer, M. (2023). Avapritinib versus Placebo in Indolent Systemic Mastocytosis. NEJM Evidence, 2(6). https://doi.org/10.1056/evidoa2200339
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DeAngelo, D. J., Pullarkat, V. A., Piris-Villaespesa, M., George, T. I., Patel, J. L., Ustun, C., Bose, P., Heaney, M. L., Sachs, J., Sun, L., Pilla, A., Exter, B., Jolin, H. A., & Tashi, T. (2022). Preliminary Safety and Efficacy from Apex, a Phase 2 Study of Bezuclastinib (CGT9486), a Novel, Highly Selective, Potent KIT D816V Tyrosine Kinase Inhibitor, in Adults with Advanced Systemic Mastocytosis (AdvSM). Blood, 140(Supplement 1), 1512–1513. https://doi.org/10.1182/blood-2022-156311
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DeAngelo, D. J., Pullarkat, V., Piris-Villaespesa, M., George, T. I., Patel, J. L., Ustun, C., Bose, P., Heaney, M. L., Pilla, A., Massaro, M., Exter, B., Jolin, H. A., Mikhak, Z., & Tashi, T. (2022). P1049: A Phase 2 Study of Bezuclastinib (CGT9486), a Novel, Highly Selective, Potent Kit D816V Inhibitor, in Adults With Advanced Systemic Mastocytosis (Apex): Methods, Baseline Data, and Early Insights. HemaSphere, 6, 939–940. https://doi.org/10.1097/01.hs9.0000847064.38588.9b

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Steers, N. J., Gupta, Y., D’Agati, V. D., Lim, T. Y., DeMaria, N., Mo, A., Liang, J., Stevens, K. O., Ahram, D. F., Lam, W. Y., Gagea, M., Nagarajan, L., Sanna-Cherchi, S., & Gharavi, A. G. (2022). GWAS in Mice Maps Susceptibility to HIV-Associated Nephropathy to the Ssbp2 Locus. Journal of the American Society of Nephrology, 33(1), 108–120. https://doi.org/10.1681/asn.2021040543
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Gotlib, J., Reiter, A., Radia, D. H., Deininger, M. W., George, T. I., Panse, J., Vannucchi, A. M., Platzbecker, U., Alvarez-Twose, I., Mital, A., Hermine, O., Dybedal, I., Hexner, E. O., Hicks, L. K., Span, L., Mesa, R., Bose, P., Pettit, K. M., Heaney, M. L., … DeAngelo, D. J. (2021). Efficacy and safety of avapritinib in advanced systemic mastocytosis: interim analysis of the phase 2 PATHFINDER trial. Nature Medicine, 27(12), 2192–2199. https://doi.org/10.1038/s41591-021-01539-8
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