Role of Hippo Signaling Pathway in Mechanotransduction

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Kizhatil, K., Clark, G. M., Sunderland, D. K., Bhandari, A., Horbal, L. J., Balasubramanian, R., & John, S. W. M. (2025). FYN regulates aqueous humor outflow and IOP through the phosphorylation of VE-CADHERIN. Nature Communications, 16(1). https://doi.org/10.1038/s41467-024-55232-8
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Zhang, F., Sahu, V., Peng, K., Wang, Y., Li, T., Bala, P., Aitymbayev, D., Sahgal, P., Schaefer, A., Der, C. J., Ryeom, S., Yoon, S., Sethi, N., Bass, A. J., & Zhang, H. (2024). Recurrent RhoGAP gene fusion CLDN18-ARHGAP26 promotes RHOA activation and focal adhesion kinase and YAP-TEAD signalling in diffuse gastric cancer. Gut, 73(8), 1280–1291. https://doi.org/10.1136/gutjnl-2023-329686
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Wu, C., Cai, X., Wang, Y., Rodriguez, C. D., Zoaldi, G., Herrmann, L., Huang, C.-Y., Wang, X., Sanghvi, V. R., Lu, R. O., & Meng, Z. (2024). Interplay of RAP2 GTPase and the cytoskeleton in Hippo pathway regulation. Journal of Biological Chemistry, 300(5), 107257. https://doi.org/10.1016/j.jbc.2024.107257
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Saito, Y., Yin, D., Kubota, N., Wang, X., Filliol, A., Remotti, H., Nair, A., Fazlollahi, L., Hoshida, Y., Tabas, I., Wangensteen, K. J., & Schwabe, R. F. (2023). A Therapeutically Targetable TAZ-TEAD2 Pathway Drives the Growth of Hepatocellular Carcinoma via ANLN and KIF23. Gastroenterology, 164(7), 1279–1292. https://doi.org/10.1053/j.gastro.2023.02.043
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Chaudhary, K. R., Kinslow, C. J., Cheng, H., Silva, J. M., Yu, J., Wang, Tony. J., Hei, T. K., Halmos, B., & Cheng, S. K. (2022). Smurf2 inhibition enhances chemotherapy and radiation sensitivity in non-small-cell lung cancer. Scientific Reports, 12(1). https://doi.org/10.1038/s41598-022-14448-8
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Lee, S. B., Garofano, L., Ko, A., D’Angelo, F., Frangaj, B., Sommer, D., Gan, Q., Kim, K., Cardozo, T., Iavarone, A., & Lasorella, A. (2022). Regulated interaction of ID2 with the anaphase-promoting complex links progression through mitosis with reactivation of cell-type-specific transcription. Nature Communications, 13(1). https://doi.org/10.1038/s41467-022-29502-2
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Ballout, F., Lu, H., Chen, L., Sriramajayam, K., Que, J., Meng, Z., Wang, T. C., Giordano, S., Zaika, A., McDonald, O., Peng, D., & El-Rifai, W. (2022). APE1 redox function is required for activation of Yes-associated protein 1 under reflux conditions in Barrett’s-associated esophageal adenocarcinomas. Journal of Experimental & Clinical Cancer Research, 41(1). https://doi.org/10.1186/s13046-022-02472-5
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Hazra, R., Brine, L., Garcia, L., Benz, B., Chirathivat, N., Shen, M. M., Wilkinson, J. E., Lyons, S. K., & Spector, D. L. (2022). Platr4 is an early embryonic lncRNA that exerts its function downstream on cardiogenic mesodermal lineage commitment. Developmental Cell, 57(21), 2450-2468.e7. https://doi.org/10.1016/j.devcel.2022.10.002
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Zheng, L., Luo, C., Yang, N., Pei, H., Ji, M., Shu, Y., Zhang, Z., Dong, S., Wang, X., Li, X., Zhang, W., Wang, Y., Li, B., Hei, T. K., Zhou, G., & Chang, L. (2022). Ionizing radiation-induced long noncoding RNA CRYBG3 regulates YAP/TAZ through mechanotransduction. Cell Death & Disease, 13(3). https://doi.org/10.1038/s41419-022-04650-x
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