Genetic Adaptation of Lactase Persistence in Humans

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Baumeister, T., Proaño-Vasco, A., Metwaly, A., Kleigrewe, K., Kuznetsov, A., Schömig, L., Borgmann, M., Khiat, M., Anand, A., Strangmann, J., Böttcher, K., Haller, D., Dunkel, A., Somoza, V., Reiter, S., Meng, C., Thimme, R., Schmid, R. M., Patil, D. T., … Quante, M. (2025). Loss of FXR or Bile Acid-dependent Inhibition accelerate carcinogenesis of Gastroesophageal Adenocarcinoma. Cellular and Molecular Gastroenterology and Hepatology, 101505. https://doi.org/10.1016/j.jcmgh.2025.101505
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Ragab, M., Wieland, J., Ávila de Melo, C. W., Agibalova, T., Ermolova, A., Durner, N., Hempel, A., Heindl, F., Maurer, H. C., Steiger, K., Janssen, K.-P., Tschurtschenthaler, M., Wang, T. C., Quante, M., Schmid, R. M., & Middelhoff, M. (2025). Epithelial Genetic Muscarinic Receptor 3 Ablation Induces Sex-Specific Modulation of Colonic Intestinal Progenitor Cells and Response to Intestinal Injury. Journal of Crohn’s and Colitis. https://doi.org/10.1093/ecco-jcc/jjaf038
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Ahuja, K., Pathania, S., Baron, N., Khlevner, J., Bialer, M., & Mait‐Kaufman, J. (2025). Chronic atrial and intestinal dysrhythmia: A rare genetic disorder of intestinal pseudo‐obstruction. JPGN Reports. Portico. https://doi.org/10.1002/jpr3.12158
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Nishiwaki, N., Sugiura, K., Suzuki, K., Li, A. L., Contreras, C. T., Efe, G., Shin, A. E., Sadeghian, D., Zhao, J., Maitra, A., Pitarresi, J. R., Sims, P. A., Chandwani, R., & Rustgi, A. K. (2024). PRRX1 has functional roles in pancreatic acinar to ductal metaplasia and carcinogenesis. Cellular and Molecular Gastroenterology and Hepatology, 101442. https://doi.org/10.1016/j.jcmgh.2024.101442
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Sun, J., Yao, J., Olén, O., Halfvarsson, J., Bergman, D., Ebrahimi, F., Carlsson, S., Ludvigsson, J., & Ludvigsson, J. F. (2024). Bidirectional association between inflammatory bowel disease and type 1 diabetes: a nationwide matched cohort and case-control study. The Lancet Regional Health - Europe, 46, 101056. https://doi.org/10.1016/j.lanepe.2024.101056
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Lemmetyinen, T. T., Viitala, E. W., Wartiovaara, L., Päivinen, P., Virtanen, H. T., Pentinmikko, N., Katajisto, P., Mäkelä, T. P., Wang, T. C., Andressoo, J.-O., & Ollila, S. (2024). Mesenchymal GDNF promotes intestinal enterochromaffin cell differentiation. IScience, 27(12), 111246. https://doi.org/10.1016/j.isci.2024.111246
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Yuan, S., Chen, J., Li, X., Leffler, D. A., Larsson, S. C., & Ludvigsson, J. F. (2024). No association between celiac disease and female infertility: evidence from Mendelian randomization analysis. Fertility and Sterility. https://doi.org/10.1016/j.fertnstert.2024.07.001
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Yuan, S., Leffler, D., Lebwohl, B., Green, P. H. R., Sun, J., Carlsson, S., Larsson, S. C., & Ludvigsson, J. F. (2024). Coeliac disease and type 2 diabetes risk: a nationwide matched cohort and Mendelian randomisation study. Diabetologia. https://doi.org/10.1007/s00125-024-06175-8
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Shepherd, A., Feinstein, L., Sabel, S., Rastelli, D., Mezhibovsky, E., Matthews, L., Muppirala, A., Robinson, A., Sharma, K. R., ElSeht, A., Zeve, D., Breault, D. T., Gershon, M. D., & Rao, M. (2024). RET Signaling Persists in the Adult Intestine and Stimulates Motility by Limiting PYY Release From Enteroendocrine Cells. Gastroenterology, 166(3), 437–449. https://doi.org/10.1053/j.gastro.2023.11.020
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Yuan, S., Jiang, F., Chen, J., Lebwohl, B., Green, P. H. R., Leffler, D., Larsson, S. C., Li, X., & Ludvigsson, J. F. (2024). Phenome-wide Mendelian randomization analysis reveals multiple health comorbidities of coeliac disease. EBioMedicine, 101, 105033. https://doi.org/10.1016/j.ebiom.2024.105033
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Park, K. W., Yang, H., Wi, H., Ock, S. A., Lee, P., Hwang, I.-S., & Lee, B. R. (2022). Effect of Wnt signaling pathway activation on the efficient generation of bovine intestinal organoids. Journal of Animal Reproduction and Biotechnology, 37(2), 136–143. https://doi.org/10.12750/jarb.37.2.136
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Das, S., Feng, Q., Balasubramanian, I., Lin, X., Liu, H., Pellón-Cardenas, O., Yu, S., Zhang, X., Liu, Y., Wei, Z., Bonder, E. M., Verzi, M. P., Hsu, W., Zhang, L., Wang, T. C., & Gao, N. (2022). Colonic healing requires Wnt produced by epithelium as well as Tagln+ and Acta2+ stromal cells. Development, 149(1). https://doi.org/10.1242/dev.199587
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