Chronic Cerebral Hypoperfusion-Related Neurodegenerative Diseases

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Siemers, E., Feaster, T., Sethuraman, G., Sundell, K., Skljarevski, V., Cline, E. N., Zhang, H., Jerecic, J., Honig, L. S., Salloway, S., Sperling, R., Trame, M. N., Dodds, M. G., & Johnson, K. (2025). INTERCEPT-AD, a phase 1 study of intravenous sabirnetug in participants with mild cognitive impairment or mild dementia due to Alzheimer’s disease. The Journal of Prevention of Alzheimer’s Disease, 12(1), 100005. https://doi.org/10.1016/j.tjpad.2024.100005
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Wu, Y., Libby, J. B., Dumitrescu, L., De Jager, P. L., Menon, V., Schneider, J. A., Bennett, D. A., & Hohman, T. J. (2024). Association of ten VEGF family genes with Alzheimer’s disease endophenotypes at single cell resolution. Alzheimer’s & Dementia. Portico. https://doi.org/10.1002/alz.14419
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Hayden, K. M., Mielke, M. M., Evans, J. K., Neiberg, R., Molina-Henry, D., Culkin, M., Marcovina, S., Johnson, K. C., Carmichael, O. T., Rapp, S. R., Sachs, B. C., Ding, J., Shappell, H., Wagenknecht, L., Luchsinger, J. A., & Espeland, M. A. (2024). Association between Modifiable Risk Factors and Levels of Blood-Based Biomarkers of Alzheimer’s and Related Dementias in the Look AHEAD Cohort. The Journal of Aging Research & Lifestyle. https://doi.org/10.14283/jarlife.2024.1
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Solé-Guardia, G., Custers, E., de Lange, A., Clijncke, E., Geenen, B., Gutierrez, J., Küsters, B., Claassen, J. A. H. R., de Leeuw, F.-E., Wiesmann, M., & Kiliaan, A. J. (2023). Association between hypertension and neurovascular inflammation in both normal-appearing white matter and white matter hyperintensities. Acta Neuropathologica Communications, 11(1). https://doi.org/10.1186/s40478-022-01497-3
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Dage, J. L., Eloyan, A., Thangarajah, M., Hammers, D. B., Fagan, A. M., Gray, J. D., Schindler, S. E., Snoddy, C., Nudelman, K. N. H., Faber, K. M., Foroud, T., Aisen, P., Griffin, P., Grinberg, L. T., Iaccarino, L., Kirby, K., Kramer, J., Koeppe, R., … Kukull, W. A. (2023). Cerebrospinal fluid biomarkers in the Longitudinal Early‐onset Alzheimer’s Disease Study. Alzheimer’s & Dementia, 19(S9). Portico. https://doi.org/10.1002/alz.13399
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Seto, M., Dumitrescu, L., Mahoney, E. R., Sclafani, A. M., De Jager, P. L., Menon, V., Koran, M. E. I., Robinson, R. A., Ruderfer, D. M., Cox, N. J., Seyfried, N. T., Jefferson, A. L., Schneider, J. A., Bennett, D. A., Petyuk, V. A., & Hohman, T. J. (2023). Multi-omic characterization of brain changes in the vascular endothelial growth factor family during aging and Alzheimer’s disease. Neurobiology of Aging, 126, 25–33. https://doi.org/10.1016/j.neurobiolaging.2023.01.010
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Winfree, R. L., Seto, M., Dumitrescu, L., Menon, V., De Jager, P., Wang, Y., Schneider, J., Bennett, D. A., Jefferson, A. L., & Hohman, T. J. (2023). TREM2 gene expression associations with Alzheimer’s disease neuropathology are region-specific: implications for cortical versus subcortical microglia. Acta Neuropathologica, 145(6), 733–747. https://doi.org/10.1007/s00401-023-02564-2
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Marshall, R. S., Liebeskind, D. S., III, J. H., Edwards, L. J., Howard, G., Meschia, J. F., Brott, T. G., Lal, B. K., Heck, D., Lanzino, G., Sangha, N., Kashyap, V. S., Morales, C. D., Cotton-Samuel, D., Rivera, A. M., Brickman, A. M., & Lazar, R. M. (2023). Cortical Thinning in High-Grade Asymptomatic Carotid Stenosis. Journal of Stroke, 25(1), 92–100. https://doi.org/10.5853/jos.2022.02285
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Pichet Binette, A., Franzmeier, N., Spotorno, N., Ewers, M., Brendel, M., Biel, D., Weiner, M., Aisen, P., Petersen, R., Jack, C. R., Jagust, W., Trojanowki, J. Q., Toga, A. W., Beckett, L., Green, R. C., Saykin, A. J., Morris, J., Shaw, L. M., … Hansson, O. (2022). Amyloid-associated increases in soluble tau relate to tau aggregation rates and cognitive decline in early Alzheimer’s disease. Nature Communications, 13(1). https://doi.org/10.1038/s41467-022-34129-4
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Connor, S. M., Rashid, M., Ryan, K. J., Patel, K., Boyd, J. D., Smith, J., Elyaman, W., Bennett, D. A., & Bradshaw, E. M. (2022). GW5074 Increases Microglial Phagocytic Activities: Potential Therapeutic Direction for Alzheimer’s Disease. Frontiers in Cellular Neuroscience, 16. https://doi.org/10.3389/fncel.2022.894601
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