Genomic Aberrations and Treatment of Chronic Lymphocytic Leukemia

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Pal, I., Grilo, A. M. S., Gaspary, A., Das Sharma, S., Scotto, L., O’Connor, O. A., Jovanovic, M., Deng, C., & Berchowitz, L. E. (2022). Inhibition of casein kinase 1δ disrupts translation initiation and exerts potent antilymphoma activity. Blood Advances, 6(14), 4157–4161. https://doi.org/10.1182/bloodadvances.2021006833
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Keren, D. F., Bocsi, G., Billman, B. L., Etzell, J., Faix, J. D., Kumar, S., Lipe, B., McCudden, C., Montgomery, R., Murray, D. L., Rai, A. J., Redondo, T. C., Souter, L., Ventura, C. B., & Ansari, M. Q. (2021). Laboratory Detection and Initial Diagnosis of Monoclonal Gammopathies. Archives of Pathology & Laboratory Medicine, 146(5), 575–590. https://doi.org/10.5858/arpa.2020-0794-cp
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Diamond, J. R., Boni, V., Lim, E., Nowakowski, G., Cordoba, R., Morillo, D., Valencia, R., Genvresse, I., Merz, C., Boix, O., Frigault, M. M., Greer, J. M., Hamdy, A. M., Huang, X., Izumi, R., Wong, H., & Moreno, V. (2022). First-in-Human Dose-Escalation Study of Cyclin-Dependent Kinase 9 Inhibitor VIP152 in Patients with Advanced Malignancies Shows Early Signs of Clinical Efficacy. Clinical Cancer Research, 28(7), 1285–1293. https://doi.org/10.1158/1078-0432.ccr-21-3617
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Gregory, G. P., Kumar, S., Wang, D., Mahadevan, D., Walker, P., Wagner-Johnston, N., Escobar, C., Bannerji, R., Bhutani, D., Chang, J., Hernandez-Ilizaliturri, F. J., Klein, A., Pagel, J. M., Rybka, W., Yee, A. J., Mohrbacher, A., Huang, M., Farooqui, M., Marinello, P., & Quach, H. (2022). Pembrolizumab plus dinaciclib in patients with hematologic malignancies: the phase 1b KEYNOTE-155 study. Blood Advances, 6(4), 1232–1242. https://doi.org/10.1182/bloodadvances.2021005872
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Mato, A. R., Davids, M. S., Sharman, J., Roeker, L. E., Kay, N., Kater, A. P., Rogers, K., Thompson, M. C., Rhodes, J., Goy, A., Skarbnik, A., Schuster, S. J., Tam, C. S., Eyre, T. A., O’Brien, S., Nabhan, C., Lamanna, N., Sun, C., Shadman, M., … Woyach, J. A. (2021). Recognizing Unmet Need in the Era of Targeted Therapy for CLL/SLL: “What’s Past Is Prologue” (Shakespeare). Clinical Cancer Research, 28(4), 603–608. https://doi.org/10.1158/1078-0432.ccr-21-1237
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Gibson, S. E., Liu, Y.-C., Yatsenko, S. A., Barasch, N. J., & Swerdlow, S. H. (2022). Histopathologic, immunophenotypic, and mutational landscape of follicular lymphomas with plasmacytic differentiation. Modern Pathology, 35(1), 60–68. https://doi.org/10.1038/s41379-021-00938-z
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van Vollenhoven, R. F., Bertsias, G., Doria, A., Isenberg, D., Morand, E., Petri, M. A., Pons-Estel, B. A., Rahman, A., Ugarte-Gil, M. F., Voskuyl, A., Arnaud, L., Bruce, I. N., Cervera, R., Costedoat-Chalumeau, N., Gordon, C., Houssiau, F. A., Mosca, M., Schneider, M., Ward, M. M., … Aranow, C. (2021). 2021 DORIS definition of remission in SLE: final recommendations from an international task force. Lupus Science & Medicine, 8(1), e000538. https://doi.org/10.1136/lupus-2021-000538
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Lipsky, A. H., Hill, B. T., Winter, A. M., Jurcic, J. G., Heaney, M. L., Rosenblat, T. L., Chiaramonte, M., Weissbrot, H., & Lamanna, N. (2021). High Rates of Undetectable Minimal Residual Disease Remissions with Time-Limited Bendamustine, Rituximab, and Venetoclax (BR-VR) in Untreated Chronic Lymphocytic Leukemia (CLL). Blood, 138(Supplement 1), 1555–1555. https://doi.org/10.1182/blood-2021-150914
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Pemmaraju, N., Kantarjian, H., Sweet, K., Wang, E. S., Lane, A. A., Ali, H., Stein, A. S., Yacoub, A., Rizzieri, D. A., Vasu, S., Gupta, V., Lee, S., Schiller, G. J., Foran, J. M., Taparia, M. S., Rosenblat, T. L., Walter, R. B., Sieminski, D., Anant, M., … Konopleva, M. (2021). Integrated Safety Analysis of Tagraxofusp, a CD123-Directed Targeted Therapy, in Patients with Hematologic Malignancies. Blood, 138(Supplement 1), 2318–2318. https://doi.org/10.1182/blood-2021-145344
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Ricker, E. C., Ryu, Y. K., & Amengual, J. E. (2021). Daratumumab Plus Chemotherapy Induces Complete Responses in a Consecutive Series of Four Patients with Plasmablastic Lymphoma. Blood, 138(Supplement 1), 4573–4573. https://doi.org/10.1182/blood-2021-150800
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Koffman, Dr. B., Stewart, C., Avruch, L., Bailey, N., Brumble, R., Byrd, J. C., Danilov, A. V., Davids, M. S., Furman, R., Jain, N., Kay, N. E., Lamanna, N., Mato, A. R., Skarbnik, A., Ujjani, C. S., & Pagel, J. M. (2021). Awareness, Knowledge, and Preferences of United States (US) Patients with Chronic Lymphocytic Leukemia (CLL) and Their Caregivers Related to Finite Duration (FD) Therapy and Minimal (Measurable) Residual Disease (MRD). Blood, 138(Supplement 1), 1927–1927. https://doi.org/10.1182/blood-2021-145046
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Thompson, M. C., Roeker, L. E., Coombs, C. C., Jensen, J. L., Kamdar, M., Skarbnik, A., Pagel, J. M., Bailey, N., Pu, J. J., Jacobs, R., Hill, B. T., Brander, D. M., Shadman, M., Ujjani, C. S., Battiato, K. E., Komari, C. J., Sacchi De Camargo Correia, G., Aronson, J. H., Rhodes, J. M., … Mato, A. R. (2021). Addressing a New Challenge in Chronic Lymphocytic Leukemia: Outcomes of Therapies after Exposure to Both a Covalent Bruton’s Tyrosine Kinase Inhibitor and Venetoclax. Blood, 138(Supplement 1), 2628–2628. https://doi.org/10.1182/blood-2021-150751
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Love, C., Pillai, R., Ondrejka, S. L., Bhagat, G., Chadburn, A., McKinney, M., Koff, J. L., Soliman, D. S., Czader, M., Louissaint, A., Li, S., Ong, C. K., Behdad, A., Evens, A. M., Natkunam, Y., Norgaard, P. H., Leppa, S., Tse, E., Chapman, J. R., … Dave, S. (2021). The Atlas of Blood Cancer Genomes (ABCG) Project: A Comprehensive Molecular Characterization of Leukemias and Lymphomas. Blood, 138(Supplement 1), 2213–2213. https://doi.org/10.1182/blood-2021-151346
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Wang, M., Shah, N. N., Alencar, A. J., Gerson, J. N., Patel, M. R., Fakhri, B., Jurczak, W., Tan, X. N., Lewis, K., Fenske, T. S., Coombs, C. C., Flinn, I. W., Lewis, D. J., Le Gouill, S., Palomba, M. L., Woyach, J. A., Pagel, J. M., Lamanna, N., Cohen, J. B., … Cheah, C. Y. (2021). Pirtobrutinib, A Next Generation, Highly Selective, Non-Covalent BTK Inhibitor in Previously Treated Mantle Cell Lymphoma: Updated Results from the Phase 1/2 BRUIN Study. Blood, 138(Supplement 1), 381–381. https://doi.org/10.1182/blood-2021-149138
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Hijiya, N., Kapoor, S., Descamps, L., Bayar, M. A., & Ramscar, N. (2021). Trial in Progress: A Multicenter, Open-Label, Phase Ib/II Study to Determine the Dose and Safety of Asciminib in Pediatric Patients with Philadelphia Chromosome-Positive Chronic Myeloid Leukemia in Chronic Phase Treated with ≥1 Prior Tyrosine Kinase Inhibitor. Blood, 138(Supplement 1), 2561–2561. https://doi.org/10.1182/blood-2021-151198
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Prockop, S., Mahadeo, K. M., Beitinjaneh, A., Choquet, S., Stiff, P., Reshef, R., Satyanarayana, G., Dahiya, S., Parmar, H., Ye, W., Gamelin, L., & Dinavahi, R. (2021). Multicenter, Open-Label, Phase 3 Study of Tabelecleucel for Solid Organ or Allogeneic Hematopoietic Cell Transplant Recipients with Epstein-Barr Virus-Driven Post Transplant Lymphoproliferative Disease after Failure of Rituximab or Rituximab and Chemotherapy (ALLELE). Blood, 138(Supplement 1), 301–301. https://doi.org/10.1182/blood-2021-147274
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Youn, M., Smith, S. M., Lee, A. G., Chae, H.-D., Spiteri, E., Erdmann, J., Galperin, I., Murphy, L. C., Donato, M., Abidi, P., Bittencourt, H., Lacayo, N. J., Dahl, G., Aftandilian, C., Davis, K. L., Matthews, J. A., Kornblau, S. M., Huang, M., Sumarsono, N., … Sakamoto, K. M. (2021). Gene Expression Analysis of CML Patients across the Age Spectrum. Blood, 138(Supplement 1), 1473–1473. https://doi.org/10.1182/blood-2021-148701
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Pennesi, E., Brivio, E., Willemse, M. E., Huitema, A. D. R., Chandra, S., Vijayakumar, A., Van Der Velden, V. H. J., Beverloo, H. B., Durairaj, C., Viqueira, A., Ingrosso, A., Locatelli, F., Motwani, J., Bourquin, J.-P., Bautista Sirvent, F. J., Rizzari, C., Petit, A., Lancaster, D., Metzler, M., … Zwaan, C. M. (2021). A Phase I/II Study of Bosutinib in Pediatric Patients with Resistant/Intolerant or Newly Diagnosed Philadelphia Chromosome-Positive Chronic Myeloid Leukemia, Study ITCC (Innovative Therapies for Children with Cancer European Consortium) 054 and COG (Children’s Oncology Group Consortium) AAML1921: Results from the Phase I Trial in Resistant/Intolerant Patients. Blood, 138(Supplement 1), 2558–2558. https://doi.org/10.1182/blood-2021-145709
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Mato, A. R., Pagel, J. M., Coombs, C. C., Shah, N. N., Lamanna, N., Munir, T., Lech-Marańda, E., Eyre, T. A., Woyach, J. A., Wierda, W. G., Cheah, C. Y., Cohen, J. B., Roeker, L. E., Patel, M. R., Fakhri, B., Barve, M. A., Tam, C. S., Lewis, D. J., Gerson, J. N., … Jurczak, W. (2021). Pirtobrutinib, A Next Generation, Highly Selective, Non-Covalent BTK Inhibitor in Previously Treated CLL/SLL: Updated Results from the Phase 1/2 BRUIN Study. Blood, 138(Supplement 1), 391–391. https://doi.org/10.1182/blood-2021-147599
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Lee, H. J., Choi, M., Siddiqi, T., Barrientos, J., Wierda, W. G., Isufi, I., Tuscano, J., Lamanna, N., Subbiah, S., Koff, J. L., Leslie, L. A., Goldenberg, A., Chung, G. G., Breitmeyer, J. B., Yazji, S., Wang, Y., Wang, M., Jamieson, C., & Kipps, T. J. (2021). Phase 1b/2 Study of Cirmtuzumab and Ibrutinib in Mantle Cell Lymphoma (MCL) or Chronic Lymphocytic Leukemia (CLL). Blood, 138(Supplement 1), 3534–3534. https://doi.org/10.1182/blood-2021-148779
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Herrera, A. F., Ahn, K. W., Litovich, C., Chen, Y., Assal, A., Bashir, Q., Bayer, R.-L., Coleman, M., DeFilipp, Z., Farhadfar, N., Greenwood, M., Hahn, T., Horwitz, M., Jacobson, C., Jaglowski, S., Lachance, S., Langston, A., Mattar, B., Maziarz, R. T., … Hamadani, M. (2021). Autologous and allogeneic hematopoietic cell transplantation for diffuse large B-cell lymphoma–type Richter syndrome. Blood Advances, 5(18), 3528–3539. https://doi.org/10.1182/bloodadvances.2021004865
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