Discovering selective antiferroptotic inhibitors of the 15LOX/PEBP1 complex noninterfering with biosynthesis of lipid mediators

Dar, H. H., Mikulska-Ruminska, K., Tyurina, Y. Y., Luci, D. K., Yasgar, A., Samovich, S. N., Kapralov, A. A., Souryavong, A. B., Tyurin, V. A., Amoscato, A. A., Epperly, M. W., Shurin, G. V., Standley, M., Holman, T. R., St. Croix, C. M., Watkins, S. C., VanDemark, A. P., Rana, S., Zakharov, A. V., … Kagan, V. E. (2023). Discovering selective antiferroptotic inhibitors of the 15LOX/PEBP1 complex noninterfering with biosynthesis of lipid mediators. Proceedings of the National Academy of Sciences, 120(25). https://doi.org/10.1073/pnas.2218896120
Authors:
Haider H Dar
Karolina Mikulska-Ruminska
Yulia Y Tyurina
Diane K Luci
Adam Yasgar
Svetlana N Samovich
Alexander A Kapralov
Austin B Souryavong
Vladimir A Tyurin
Andrew A Amoscato
Michael W Epperly
Galina V Shurin
Melissa Standley
Theodore R Holman
Claudette M St Croix
Simon C Watkins
Andrew P VanDemark
Sandeep Rana
Alexey V Zakharov
Anton Simeonov
Juan Marugan
Rama K Mallampalli
Sally E Wenzel
Joel S Greenberger
Ganesha Rai
Hülya Bayir
Ivet Bahar
Valerian E Kagan
Affiliated Authors:
Hülya Bayir
Author Keywords:
15-lipoxygenase
ferroptosis
inhibitor design
lipid peroxidation
pebp1
Publication Type:
Article
Unique ID:
10.1073/pnas.2218896120
PMID:
Publication Date:
Data Source:
PubMed

Record Created: