Caspase-4/11 exacerbates disease severity in SARS-CoV-2 infection by promoting inflammation and immunothrombosis

Eltobgy, M. M., Zani, A., Kenney, A. D., Estfanous, S., Kim, E., Badr, A., Carafice, C., Daily, K., Whitham, O., Pietrzak, M., Webb, A., Kawahara, J., Eddy, A. C., Denz, P., Lu, M., KC, M., Peeples, M. E., Li, J., Zhu, J., … Amer, A. O. (2022). Caspase-4/11 exacerbates disease severity in SARS–CoV-2 infection by promoting inflammation and immunothrombosis. Proceedings of the National Academy of Sciences, 119(21). https://doi.org/10.1073/pnas.2202012119
Authors:
Mostafa M Eltobgy
Ashley Zani
Adam D Kenney
Shady Estfanous
Eunsoo Kim
Asmaa Badr
Cierra Carafice
Kylene Daily
Owen Whitham
Maciej Pietrzak
Amy Webb
Jeffrey Kawahara
Adrian C Eddy
Parker Denz
Mijia Lu
Mahesh Kc
Mark E Peeples
Jianrong Li
Jian Zhu
Jianwen Que
Richard Robinson
Oscar Rosas Mejia
Rachael E Rayner
Luanne Hall-Stoodley
Stephanie Seveau
Mikhail A Gavrilin
Xiaoli Zhang
Jeronay Thomas
Jacob E Kohlmeier
Mehul S Suthar
Eugene Oltz
Andrea Tedeschi
Frank H Robledo-Avila
Santiago Partida-Sanchez
Emily A Hemann
Eman Abdelrazik
Adriana Forero
Shahid M Nimjee
Prosper N Boyaka
Estelle Cormet-Boyaka
Jacob S Yount
Amal O Amer
Affiliated Authors:
Jianwen Que
Columbia Affiliation:
Subjects:
COVID-19 (MeSH)
Caspases, Initiator (MeSH)
SARS-CoV-2 (MeSH)
Thromboinflammation (MeSH)
Author Keywords:
innate immunity
sars-cov-2
thrombosis
sars–cov-2
elink
Publication Type:
Article
Unique ID:
10.1073/pnas.2202012119
PMID:
35588457
DOI:
10.1073/pnas.2202012119
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record
View Web of Science Record

Record Created: