Huntington disease oligodendrocyte maturation deficits revealed by single-nucleus RNAseq are rescued by thiamine-biotin supplementation

Lim, R. G., Al-Dalahmah, O., Wu, J., Gold, M. P., Reidling, J. C., Tang, G., Adam, M., Dansu, D. K., Park, H.-J., Casaccia, P., Miramontes, R., Reyes-Ortiz, A. M., Lau, A., Hickman, R. A., Khan, F., Paryani, F., Tang, A., Ofori, K., Miyoshi, E., … Thompson, L. M. (2022). Huntington disease oligodendrocyte maturation deficits revealed by single-nucleus RNAseq are rescued by thiamine-biotin supplementation. Nature Communications, 13(1). https://doi.org/10.1038/s41467-022-35388-x
Authors:
Ryan G Lim
Osama Al-Dalahmah
Jie Wu
Maxwell P Gold
Jack C Reidling
Guomei Tang
Miriam Adam
David K Dansu
Hye-Jin Park
Patrizia Casaccia
Ricardo Miramontes
Andrea M Reyes-Ortiz
Alice Lau
Richard A Hickman
Fatima Khan
Fahad Paryani
Alice Tang
Kenneth Ofori
Emily Miyoshi
Neethu Michael
Nicolette McClure
Xena E Flowers
Jean Paul Vonsattel
Shawn Davidson
Vilas Menon
Vivek Swarup
Ernest Fraenkel
James E Goldman
Leslie M Thompson
Affiliated Authors:
Osama Al-Dalahmah
Guomei Tang
Richard A Hickman
Fatima Khan
Fahad Paryani
Alice Tang
Kenneth Ofori
Xena E Flowers
Jean Paul Vonsattel
Vilas Menon
James E Goldman
Columbia Affiliation:
Subjects:
Biotin (MeSH)
Huntington Disease (MeSH)
Oligodendroglia (MeSH)
Thiamine (MeSH)
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Publication Type:
Article
Unique ID:
10.1038/s41467-022-35388-x
PMID:
36543778
DOI:
10.1038/s41467-022-35388-x
Journal:
Nature Communications
Publication Date:
Data Source:
PubMed
Source Link:
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