Deconvoluting clonal and cellular architecture in IDH-mutant acute myeloid leukemia

Sirenko, M., Lee, S., Sun, Z., Chaligne, R., Loghavi, S., Asimomitis, G., Brierley, C. K., Bernard, E., Cai, S. F., Myers, R. M., Nadorp, B., Sango, J., Lallo, M., Levine, M. F., Domenico, D., Arango Ossa, J. E., Medina-Martinez, J. S., Menghrajani, K., Lasry, A., … Papaemmanuil, E. (2025). Deconvoluting clonal and cellular architecture in IDH-mutant acute myeloid leukemia. Cell Stem Cell. https://doi.org/10.1016/j.stem.2025.04.012
Authors:
Maria Sirenko
Soobeom Lee
Zhengxi Sun
Ronan Chaligne
Sanam Loghavi
Georgios Asimomitis
Charlotte K Brierley
Elsa Bernard
Sheng F Cai
Robert M Myers
Bettina Nadorp
Junya Sango
Morgan Lallo
Max F Levine
Dylan Domenico
Juan E Arango Ossa
Juan S Medina-Martinez
Kamal Menghrajani
Audrey Lasry
Alice S Mims
Helee Desai
Andrea Laganson
Chris Famulare
Minal Patel
Gerard Lozanski
Kelly L Bolton
Aaron D Viny
Mikhail Roshal
Ross L Levine
Eirini P Papapetrou
Eytan M Stein
Dan A Landau
Ann-Kathrin Eisfeld
Iannis Aifantis
Elli Papaemmanuil
Affiliated Authors:
Aaron D Viny
Columbia Affiliation:
Author Keywords:
idh inhibitors
idh1/2 mutations
acute myeloid leukemia
cellular hierarchy
clonal architecture
clonal evolution
relapse
single-cell transcriptomics
targeted therapy
treatment resistance
elink
Publication Type:
Article
Unique ID:
10.1016/j.stem.2025.04.012
PMID:
40409258
DOI:
10.1016/j.stem.2025.04.012
Journal:
Cell Stem Cell
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record

Record Created: