CLU alleviates Alzheimer's disease-relevant processes by modulating astrocyte reactivity and microglia-dependent synaptic density

Lish, A. M., Grogan, E. F. L., Benoit, C. R., Pearse, R. V., Heuer, S. E., Luquez, T., Orme, G. A., Galle, P. C., Milinkeviciute, G., Green, K. N., Alexander, K. D., Fancher, S. B., Stern, A. M., Fujita, M., Bennett, D. A., Seyfried, N. T., De Jager, P. L., Menon, V., & Young-Pearse, T. L. (2025). CLU alleviates Alzheimer’s disease-relevant processes by modulating astrocyte reactivity and microglia-dependent synaptic density. Neuron. https://doi.org/10.1016/j.neuron.2025.03.034
Authors:
Alexandra M Lish
Elyssa F L Grogan
Courtney R Benoit
Richard V Pearse
Sarah E Heuer
Tain Luquez
Gwendolyn A Orme
Paige C Galle
Giedre Milinkeviciute
Kim N Green
Kellianne D Alexander
Seeley B Fancher
Andrew M Stern
Masashi Fujita
David A Bennett
Nicholas T Seyfried
Philip L De Jager
Vilas Menon
Tracy L Young-Pearse
Affiliated Authors:
Tain Luquez
Masashi Fujita
Philip L De Jager
Vilas Menon
Columbia Affiliation:
Author Keywords:
alzheimer's disease
apoe
astrocyte reactivity
astrocyte-microglia crosstalk
clusterin
complement
human ipsc cells
risk variants
synapse density
tau
alzheimer’s disease
elink
Publication Type:
Article
Unique ID:
10.1016/j.neuron.2025.03.034
PMID:
40311610
DOI:
10.1016/j.neuron.2025.03.034
Journal:
Neuron
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record
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