MT-125 inhibits non-muscle myosin IIA and IIB and prolongs survival in glioblastoma

Kenchappa, R. S., Radnai, L., Young, E. J., Zarco, N., Lin, L., Dovas, A., Meyer, C. T., Haddock, A., Hall, A., Toth, K., Canoll, P., Nagaiah, N. K. H., Rumbaugh, G., Cameron, M. D., Kamenecka, T. M., Griffin, P. R., Miller, C. A., & Rosenfeld, S. S. (2025). MT-125 inhibits non-muscle myosin IIA and IIB and prolongs survival in glioblastoma. Cell. https://doi.org/10.1016/j.cell.2025.05.019
Authors:
Rajappa S Kenchappa
Laszlo Radnai
Erica J Young
Natanael Zarco
Li Lin
Athanassios Dovas
Christian T Meyer
Ashley Haddock
Alice Hall
Katalin Toth
Peter Canoll
Naveen K H Nagaiah
Gavin Rumbaugh
Michael D Cameron
Theodore M Kamenecka
Patrick R Griffin
Courtney A Miller
Steven S Rosenfeld
Affiliated Authors:
Athanassios Dovas
Peter Canoll
Columbia Affiliation:
Subjects:
Biogenesis and Functions of Circular RNAs (OpenAlex Topic)
Mechanisms and Implications of Ferroptosis in Cancer (OpenAlex Topic)
Gliomas (OpenAlex Topic)
Author Keywords:
cancer
glioblastoma
non-muscle myosin ii
oncogenic kinases
reactive oxygen species
small-molecule inhibitor
synergy
targeted therapy
toxicology
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Publication Type:
Article
Unique ID:
10.1016/j.cell.2025.05.019
PMID:
40499543
DOI:
10.1016/j.cell.2025.05.019
Journal:
Cell
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record
View OpenAlex Record

Record Created: