Dual Inhibition of Histone Deacetylases and the Mechanistic Target of Rapamycin Promotes Apoptosis in Cell Line Models of Uveal Melanoma

Patel, R. P., Thomas, J. R., Curt, K. M., Fitzsimmons, C. M., Batista, P. J., Bates, S. E., Gottesman, M. M., & Robey, R. W. (2021). Dual Inhibition of Histone Deacetylases and the Mechanistic Target of Rapamycin Promotes Apoptosis in Cell Line Models of Uveal Melanoma. Investigative Opthalmology & Visual Science, 62(12), 16. https://doi.org/10.1167/iovs.62.12.16
Authors:
Ruchi P Patel
Joanna R Thomas
Katherine M Curt
Christina M Fitzsimmons
Pedro J Batista
Susan E Bates
Michael M Gottesman
Robert W Robey
Affiliated Authors:
Susan E Bates
Columbia Affiliation:
Subjects:
Ocular Cancer Research and Treatment (OpenAlex Topic)
Role of Histone Deacetylases in Cellular Regulation (OpenAlex Topic)
Targeted Protein Degradation in Biomedical Research (OpenAlex Topic)
Apoptosis (MeSH)
Depsipeptides (MeSH)
Histone Deacetylase Inhibitors (MeSH)
Histone Deacetylases (MeSH)
Melanoma (MeSH)
Morpholines (MeSH)
TOR Serine-Threonine Kinases (MeSH)
Uveal Neoplasms (MeSH)
Author Keywords:
uveal melanoma
histone-deacetylase inhibitor
romidepsin
mtor inhibition
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Publication Type:
Article
Unique ID:
10.1167/iovs.62.12.16
PMID:
34533562
DOI:
10.1167/iovs.62.12.16
Journal:
Investigative Ophthalmology and Visual Science
Publication Date:
Data Source:
PubMed
Source Link:
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Record Created: