The power of genetic diversity in genome-wide association studies of lipids

Graham, S. E., Clarke, S. L., Wu, K.-H. H., Kanoni, S., Zajac, G. J. M., Ramdas, S., Surakka, I., Ntalla, I., Vedantam, S., Winkler, T. W., Locke, A. E., Marouli, E., Hwang, M. Y., Han, S., Narita, A., Choudhury, A., Bentley, A. R., Ekoru, K., Verma, A., … Willer, C. J. (2021). The power of genetic diversity in genome-wide association studies of lipids. Nature, 600(7890), 675–679. https://doi.org/10.1038/s41586-021-04064-3
Authors:
Sarah E Graham
Shoa L Clarke
Kuan-Han H Wu
Stavroula Kanoni
Greg J M Zajac
Shweta Ramdas
Ida Surakka
Ioanna Ntalla
Sailaja Vedantam
Thomas W Winkler
Adam E Locke
Eirini Marouli
Mi Yeong Hwang
Sohee Han
Akira Narita
Ananyo Choudhury
Amy R Bentley
Kenneth Ekoru
Anurag Verma
Bhavi Trivedi
Hilary C Martin
Karen A Hunt
Qin Hui
Derek Klarin
Xiang Zhu
Gudmar Thorleifsson
Anna Helgadottir
Daniel F Gudbjartsson
Hilma Holm
Isleifur Olafsson
Masato Akiyama
Saori Sakaue
Chikashi Terao
Masahiro Kanai
Wei Zhou
Ben M Brumpton
Humaira Rasheed
Sanni E Ruotsalainen
Aki S Havulinna
Yogasudha Veturi
QiPing Feng
Elisabeth A Rosenthal
Todd Lingren
Jennifer Allen Pacheco
Sarah A Pendergrass
Jeffrey Haessler
Franco Giulianini
Yuki Bradford
Jason E Miller
Archie Campbell
Kuang Lin
Iona Y Millwood
George Hindy
Asif Rasheed
Jessica D Faul
Wei Zhao
David R Weir
Constance Turman
Hongyan Huang
Mariaelisa Graff
Anubha Mahajan
Michael R Brown
Weihua Zhang
Ketian Yu
Ellen M Schmidt
Anita Pandit
Stefan Gustafsson
Xianyong Yin
Jian'an Luan
Jing-Hua Zhao
Fumihiko Matsuda
Hye-Mi Jang
Kyungheon Yoon
Carolina Medina-Gomez
Achilleas Pitsillides
Jouke Jan Hottenga
Gonneke Willemsen
Andrew R Wood
Yingji Ji
Zishan Gao
Simon Haworth
Ruth E Mitchell
Jin Fang Chai
Mette Aadahl
Jie Yao
Ani Manichaikul
Helen R Warren
Julia Ramirez
Jette Bork-Jensen
Line L Kårhus
Anuj Goel
Maria Sabater-Lleal
Raymond Noordam
Carlo Sidore
Edoardo Fiorillo
Aaron F McDaid
Pedro Marques-Vidal
Matthias Wielscher
Stella Trompet
Naveed Sattar
Line T Møllehave
Betina H Thuesen
Matthias Munz
Lingyao Zeng
Jianfeng Huang
Bin Yang
Alaitz Poveda
Azra Kurbasic
Claudia Lamina
Lukas Forer
Markus Scholz
Tessel E Galesloot
Jonathan P Bradfield
E Warwick Daw
Joseph M Zmuda
Jonathan S Mitchell
Christian Fuchsberger
Henry Christensen
Jennifer A Brody
Mary F Feitosa
Mary K Wojczynski
Michael Preuss
Massimo Mangino
Paraskevi Christofidou
Niek Verweij
Jan W Benjamins
Jorgen Engmann
Rachel L Kember
Roderick C Slieker
Ken Sin Lo
Nuno R Zilhao
Phuong Le
Marcus E Kleber
Graciela E Delgado
Shaofeng Huo
Daisuke D Ikeda
Hiroyuki Iha
Jian Yang
Jun Liu
Hampton L Leonard
Jonathan Marten
Börge Schmidt
Marina Arendt
Laura J Smyth
Marisa Cañadas-Garre
Chaolong Wang
Masahiro Nakatochi
Andrew Wong
Nina Hutri-Kähönen
Xueling Sim
Rui Xia
Alicia Huerta-Chagoya
Juan Carlos Fernandez-Lopez
Valeriya Lyssenko
Meraj Ahmed
Anne U Jackson
Noha A Yousri
Marguerite R Irvin
Christopher Oldmeadow
Han-Na Kim
Seungho Ryu
Paul R H J Timmers
Liubov Arbeeva
Rajkumar Dorajoo
Leslie A Lange
Xiaoran Chai
Gauri Prasad
Laura Lorés-Motta
Marc Pauper
Jirong Long
Xiaohui Li
Elizabeth Theusch
Fumihiko Takeuchi
Cassandra N Spracklen
Anu Loukola
Sailalitha Bollepalli
Sophie C Warner
Ya Xing Wang
Wen B Wei
Teresa Nutile
Daniela Ruggiero
Yun Ju Sung
Yi-Jen Hung
Shufeng Chen
Fangchao Liu
Jingyun Yang
Katherine A Kentistou
Mathias Gorski
Marco Brumat
Karina Meidtner
Lawrence F Bielak
Jennifer A Smith
Prashantha Hebbar
Aliki-Eleni Farmaki
Edith Hofer
Maoxuan Lin
Chao Xue
Jifeng Zhang
Maria Pina Concas
Simona Vaccargiu
Peter J van der Most
Niina Pitkänen
Brian E Cade
Jiwon Lee
Sander W van der Laan
Kumaraswamy Naidu Chitrala
Stefan Weiss
Martina E Zimmermann
Jong Young Lee
Hyeok Sun Choi
Maria Nethander
Sandra Freitag-Wolf
Lorraine Southam
Nigel W Rayner
Carol A Wang
Shih-Yi Lin
Jun-Sing Wang
Christian Couture
Leo-Pekka Lyytikäinen
Kjell Nikus
Gabriel Cuellar-Partida
Henrik Vestergaard
Bertha Hildalgo
Olga Giannakopoulou
Qiuyin Cai
Morgan O Obura
Jessica van Setten
Xiaoyin Li
Karen Schwander
Natalie Terzikhan
Jae Hun Shin
Rebecca D Jackson
Alexander P Reiner
Lisa Warsinger Martin
Zhengming Chen
Liming Li
Heather M Highland
Kristin L Young
Takahisa Kawaguchi
Joachim Thiery
Joshua C Bis
Girish N Nadkarni
Lenore J Launer
Huaixing Li
Mike A Nalls
Olli T Raitakari
Sahoko Ichihara
Sarah H Wild
Christopher P Nelson
Harry Campbell
Susanne Jäger
Toru Nabika
Fahd Al-Mulla
Harri Niinikoski
Peter S Braund
Ivana Kolcic
Peter Kovacs
Tota Giardoglou
Tomohiro Katsuya
Konain Fatima Bhatti
Dominique de Kleijn
Gert J de Borst
Eung Kweon Kim
Hieab H H Adams
M Arfan Ikram
Xiaofeng Zhu
Folkert W Asselbergs
Adriaan O Kraaijeveld
Joline W J Beulens
Xiao-Ou Shu
Loukianos S Rallidis
Oluf Pedersen
Torben Hansen
Paul Mitchell
Alex W Hewitt
Mika Kähönen
Louis Pérusse
Claude Bouchard
Anke Tönjes
Yii-Der Ida Chen
Craig E Pennell
Trevor A Mori
Wolfgang Lieb
Andre Franke
Claes Ohlsson
Dan Mellström
Yoon Shin Cho
Hyejin Lee
Jian-Min Yuan
Woon-Puay Koh
Sang Youl Rhee
Jeong-Taek Woo
Iris M Heid
Klaus J Stark
Henry Völzke
Georg Homuth
Michele K Evans
Alan B Zonderman
Ozren Polasek
Gerard Pasterkamp
Imo E Hoefer
Susan Redline
Katja Pahkala
Albertine J Oldehinkel
Harold Snieder
Ginevra Biino
Reinhold Schmidt
Helena Schmidt
Y Eugene Chen
Stefania Bandinelli
George Dedoussis
Thangavel Alphonse Thanaraj
Sharon L R Kardia
Norihiro Kato
Matthias B Schulze
Giorgia Girotto
Bettina Jung
Carsten A Böger
Peter K Joshi
David A Bennett
Philip L De Jager
Xiangfeng Lu
Vasiliki Mamakou
Morris Brown
Mark J Caulfield
Patricia B Munroe
Xiuqing Guo
Marina Ciullo
Jost B Jonas
Nilesh J Samani
Jaakko Kaprio
Päivi Pajukanta
Linda S Adair
Sonny Augustin Bechayda
H Janaka de Silva
Ananda R Wickremasinghe
Ronald M Krauss
Jer-Yuarn Wu
Wei Zheng
Anneke I den Hollander
Dwaipayan Bharadwaj
Adolfo Correa
James G Wilson
Lars Lind
Chew-Kiat Heng
Amanda E Nelson
Yvonne M Golightly
James F Wilson
Brenda Penninx
Hyung-Lae Kim
John Attia
Rodney J Scott
D C Rao
Donna K Arnett
Steven C Hunt
Mark Walker
Heikki A Koistinen
Giriraj R Chandak
Chittaranjan S Yajnik
Josep M Mercader
Teresa Tusié-Luna
Carlos A Aguilar-Salinas
Clicerio Gonzalez Villalpando
Lorena Orozco
Myriam Fornage
E Shyong Tai
Rob M van Dam
Terho Lehtimäki
Nish Chaturvedi
Mitsuhiro Yokota
Jianjun Liu
Dermot F Reilly
Amy Jayne McKnight
Frank Kee
Karl-Heinz Jöckel
Mark I McCarthy
Colin N A Palmer
Veronique Vitart
Caroline Hayward
Eleanor Simonsick
Cornelia M van Duijn
Fan Lu
Jia Qu
Haretsugu Hishigaki
Xu Lin
Winfried März
Esteban J Parra
Miguel Cruz
Vilmundur Gudnason
Jean-Claude Tardif
Guillaume Lettre
Leen M 't Hart
Petra J M Elders
Scott M Damrauer
Meena Kumari
Mika Kivimaki
Pim van der Harst
Tim D Spector
Ruth J F Loos
Michael A Province
Bruce M Psaty
Ivan Brandslund
Peter P Pramstaller
Kaare Christensen
Samuli Ripatti
Elisabeth Widén
Hakon Hakonarson
Struan F A Grant
Lambertus A L M Kiemeney
Jacqueline de Graaf
Markus Loeffler
Florian Kronenberg
Dongfeng Gu
Jeanette Erdmann
Heribert Schunkert
Paul W Franks
Allan Linneberg
J Wouter Jukema
Amit V Khera
Minna Männikkö
Marjo-Riitta Jarvelin
Zoltan Kutalik
Francesco Cucca
Dennis O Mook-Kanamori
Ko Willems van Dijk
Hugh Watkins
David P Strachan
Niels Grarup
Peter Sever
Neil Poulter
Jerome I Rotter
Thomas M Dantoft
Fredrik Karpe
Matt J Neville
Nicholas J Timpson
Ching-Yu Cheng
Tien-Yin Wong
Chiea Chuen Khor
Charumathi Sabanayagam
Annette Peters
Christian Gieger
Andrew T Hattersley
Nancy L Pedersen
Patrik K E Magnusson
Dorret I Boomsma
Eco J C de Geus
L Adrienne Cupples
Joyce B J van Meurs
Mohsen Ghanbari
Penny Gordon-Larsen
Wei Huang
Young Jin Kim
Yasuharu Tabara
Nicholas J Wareham
Claudia Langenberg
Eleftheria Zeggini
Johanna Kuusisto
Markku Laakso
Erik Ingelsson
Goncalo Abecasis
John C Chambers
Jaspal S Kooner
Paul S de Vries
Alanna C Morrison
Kari E North
Martha Daviglus
Peter Kraft
Nicholas G Martin
John B Whitfield
Shahid Abbas
Danish Saleheen
Robin G Walters
Michael V Holmes
Corri Black
Blair H Smith
Anne E Justice
Aris Baras
Julie E Buring
Paul M Ridker
Daniel I Chasman
Charles Kooperberg
Wei-Qi Wei
Gail P Jarvik
Bahram Namjou
M Geoffrey Hayes
Marylyn D Ritchie
Pekka Jousilahti
Veikko Salomaa
Kristian Hveem
Bjørn Olav Åsvold
Michiaki Kubo
Yoichiro Kamatani
Yukinori Okada
Yoshinori Murakami
Unnur Thorsteinsdottir
Kari Stefansson
Yuk-Lam Ho
Julie A Lynch
Daniel J Rader
Philip S Tsao
Kyong-Mi Chang
Kelly Cho
Christopher J O'Donnell
John M Gaziano
Peter Wilson
Charles N Rotimi
Scott Hazelhurst
Michèle Ramsay
Richard C Trembath
David A van Heel
Gen Tamiya
Masayuki Yamamoto
Bong-Jo Kim
Karen L Mohlke
Timothy M Frayling
Joel N Hirschhorn
Sekar Kathiresan
Michael Boehnke
Pradeep Natarajan
Gina M Peloso
Christopher D Brown
Andrew P Morris
Themistocles L Assimes
Panos Deloukas
Yan V Sun
Cristen J Willer
Affiliated Authors:
Philip L De Jager
Danish Saleheen
Columbia Affiliation:
Subjects:
Cardiovascular Diseases (MeSH)
Genome-Wide Association Study (MeSH)
Grants:
U01DP006266 (NIH – National Center for Chronic Disease Prevention and Health Promotion)
R01HL127564 (NIH – National Heart, Lung, and Blood Institute)
R35HL135824 (NIH – National Heart, Lung, and Blood Institute)
R01HL105756 (NIH – National Heart, Lung, and Blood Institute)
I01BX003362 (NIH – Veterans Affairs)
I01BX004821 (NIH – Veterans Affairs)
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Publication Type:
Article
Unique ID:
10.1038/s41586-021-04064-3
PMID:
34887591
DOI:
10.1038/s41586-021-04064-3
Journal:
Nature
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record
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