LIN28B-mediated PI3K/AKT pathway activation promotes metastasis in colorectal cancer models

Shin, A. E., Sugiura, K., Kariuki, S. W., Cohen, D. A., Flashner, S. P., Klein-Szanto, A. J., Nishiwaki, N., De, D., Vasan, N., Gabre, J. T., Lengner, C. J., Sims, P. A., & Rustgi, A. K. (2025). LIN28B-mediated PI3K/AKT pathway activation promotes metastasis in colorectal cancer models. Journal of Clinical Investigation. https://doi.org/10.1172/jci186035
Authors:
Alice E. Shin
Kensuke Sugiura
Secunda W. Kariuki
David Cohen
Samuel Flashner
Andres J. Klein‐Szanto
Noriyuki Nishiwaki
Dechokyab De
Neil Vasan
Joel Gabre
Christopher J. Lengner
Peter A. Sims
Anil K. Rustgi
Affiliated Authors:
Alice E. Shin
Kensuke Sugiura
Secunda W. Kariuki
David Cohen
Samuel Flashner
Noriyuki Nishiwaki
Dechokyab De
Neil Vasan
Joel Gabre
Peter A. Sims
Anil K. Rustgi
Columbia Affiliation:
Subjects:
Colorectal Neoplasms (MeSH)
Proto-Oncogene Proteins c-akt (MeSH)
RNA-Binding Proteins (MeSH)
Phosphatidylinositol 3-Kinases (MeSH)
Signal Transduction (MeSH)
Liver Neoplasms (MeSH)
Neoplasm Proteins (MeSH)
mTOR Signaling in Growth and Disease (OpenAlex Topic)
Author Keywords:
colorectal cancer
gastroenterology
mouse models
oncogenes
oncology
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Publication Type:
Article
Unique ID:
10.1172/jci186035
PMID:
39808497
DOI:
10.1172/jci186035
Journal:
Journal of Clinical Investigation
Publication Date:
Data Source:
OpenAlex
Source Link:
View OpenAlex Record
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Record Created: