Association of High Tumor Mutation Burden in Non-Small Cell Lung Cancers with Increased Immune Infiltration and Improved Clinical Outcomes of PD-L1 Blockade Across PD-L1 Expression Levels

Ricciuti, B., Wang, X., Alessi, J. V., Rizvi, H., Mahadevan, N. R., Li, Y. Y., Polio, A., Lindsay, J., Umeton, R., Sinha, R., Vokes, N. I., Recondo, G., Lamberti, G., Lawrence, M., Vaz, V. R., Leonardi, G. C., Plodkowski, A. J., Gupta, H., Cherniack, A. D., … Awad, M. M. (2022). Association of High Tumor Mutation Burden in Non–Small Cell Lung Cancers With Increased Immune Infiltration and Improved Clinical Outcomes of PD-L1 Blockade Across PD-L1 Expression Levels. JAMA Oncology, 8(8), 1160. https://doi.org/10.1001/jamaoncol.2022.1981
Authors:
Biagio Ricciuti
Xinan Wang
Joao V. Alessi
Hira Rizvi
Navin R. Mahadevan
Yvonne Y. Li
Andrew Polio
James Lindsay
Renato Umeton
Rileen Sinha
Natalie I. Vokes
Gonzalo Recondo
Giuseppe Lamberti
Marissa Lawrence
Victor R. Vaz
Giulia C. Leonardi
Andrew J. Plodkowski
Hersh Gupta
Andrew D. Cherniack
Michael Y. Tolstorukov
Bijaya Sharma
Kristen D. Felt
Justin F. Gainor
Arvind Ravi
Gad Getz
Kurt A. Schalper
Brian Henick
Patrick Forde
Valsamo Anagnostou
Pasi A. Jänne
Eliezer M. Van Allen
Mizuki Nishino
Lynette M. Sholl
David C. Christiani
Xihong Lin
Scott J. Rodig
Matthew D. Hellmann
Mark M. Awad
Affiliated Authors:
Brian Henick
Columbia Affiliation:
Subjects:
Cancer Immunotherapy (OpenAlex Topic)
Advancements in Lung Cancer Research (OpenAlex Topic)
Small Cell Lung Cancer (OpenAlex Topic)
Carcinoma, Non-Small-Cell Lung (MeSH)
Lung Neoplasms (MeSH)
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Publication Type:
Article
Unique ID:
10.1001/jamaoncol.2022.1981
PMID:
35708671
DOI:
10.1001/jamaoncol.2022.1981
Journal:
JAMA Oncology
Publication Date:
Data Source:
Scopus
Source Link:
View Scopus Record
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Record Created: