SLC4A11 mediates ammonia import and promotes cancer stemness in hepatocellular carcinoma

Elaimy, A. L., El-Derany, M. O., James, J., Wang, Z., Pearson, A. N., Holcomb, E. A., Huber, A. K., Gijón, M., Bell, H. N., Sanghvi, V. R., Frankel, T. L., Su, G. L., Tapper, E. B., Tai, A. W., Ramnath, N., Centonze, C. P., Dobrosotskaya, I., Moeller, J. A., Bryant, A. K., … Green, M. D. (2024). SLC4A11 mediates ammonia import and promotes cancer stemness in hepatocellular carcinoma. JCI Insight, 9(21). https://doi.org/10.1172/jci.insight.184826
Authors:
Ameer L Elaimy
Marwa O El-Derany
Jadyn James
Zhuwen Wang
Ashley N Pearson
Erin A Holcomb
Amanda K Huber
Miguel Gijón
Hannah N Bell
Viraj R Sanghvi
Timothy L Frankel
Grace L Su
Elliot B Tapper
Andrew W Tai
Nithya Ramnath
Christopher P Centonze
Irina Dobrosotskaya
Julie A Moeller
Alex K Bryant
David A Elliott
Enid Choi
Joseph R Evans
Kyle C Cuneo
Thomas J Fitzgerald
Daniel R Wahl
Meredith A Morgan
Daniel T Chang
Max S Wicha
Theodore S Lawrence
Yatrik M Shah
Michael D Green
Affiliated Authors:
Viraj R Sanghvi
Columbia Affiliation:
Subjects:
Amino Acid Transport and Metabolism in Health and Disease (OpenAlex Topic)
Ciliopathies: Genetic Disorders Involving Primary Cilia (OpenAlex Topic)
Epigenetic Modifications and Their Functional Implications (OpenAlex Topic)
Carcinoma, Hepatocellular (MeSH)
Ammonia (MeSH)
Liver Neoplasms (MeSH)
Neoplastic Stem Cells (MeSH)
Author Keywords:
amino acid metabolism
liver cancer
metabolism
oncogenes
oncology
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Publication Type:
Article
Unique ID:
10.1172/jci.insight.184826
PMID:
39287988
DOI:
10.1172/jci.insight.184826
Journal:
JCI Insight
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record
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Record Created: