Deciphering the impact of genomic variation on function

Engreitz, J. M., Lawson, H. A., Singh, H., Starita, L. M., Hon, G. C., Carter, H., Sahni, N., Reddy, T. E., Lin, X., Li, Y., Munshi, N. V., Chahrour, M. H., Boyle, A. P., Hitz, B. C., Mortazavi, A., Craven, M., Mohlke, K. L., … Samer, E. K. (2024). Deciphering the impact of genomic variation on function. Nature, 633(8028), 47–57. https://doi.org/10.1038/s41586-024-07510-0

Authors:

Ella K. Samer

Stephanie A. Morris

Carolyn M. Hutter

Daniel A. Gilchrist

Stephanie Calluori

Zo Bly

Daniel Osorio

Liang Zhang

Wei He

Rongjie Fu

Han Xu

Sandra Wittibschlager

Ana Patricia Kutschat

Davide Seruggia

John A. Morris

Christina Caragine

Neville E. Sanjana

Ching-Huang Ho

Ingrid A. Harten

John Ray

Sean Whalen

Shiron Drusinsky

Katherine S. Pollard

Axel Visel

Neil Slaven

Brandon Mannion

Michael Kosicki

Momoe Kato

Len A. Pennacchio

Anna Spiro

Alexander Sasse

Sara Mostafavi

Susie Song

Elizabeth Roberts

Maddie Murphy

Elisa Donnard

Thouis R. Jones

Corinna Losert

Matthias Heinig

Vivian Lee-Kim

Shi Fang

Rajat Gupta

Nathan Salomonis

H. Leighton Grimes

Artem Kim

Thahmina A. Ali

Kushal K. Dey

Alina Vaitsiankova

Tanay Thakar

Angelo Taglialatela

Giuseppe Leuzzi

Jen-Wei Huang

Samuel B. Hayward

Alberto Ciccia

Kristen Brennand

Xiaoyu Zhuo

Guoyan Zhao

Bo Zhang

Wenjin Zhang

Juan Wang

Chad Tomlinson

Barbara E. Stranger

Nathan Stitziel

Kara Quaid

Karen H. Miga

Juan Macias-Velasco

Xiaowen Ma

Huijue Lyu

Yuan Luo

Yu Luan

Tina Lindsay

Daofeng Li

Lucinda Fulton

Changxu Fan

Patricia Dickson

Rex L. Chisholm

Xintong Chen

Eddie Belter

Cricket A. Sloan

Ingrid A. Youngworth

Ian M. Whaling

Forrest Y. Tanaka

Emma Spragins

Corinn Small

Joel Rozowsky

Stuart R. Miyasato

Khine Lin

Mingjie Li

Jin-Wook Lee

Meenakshi S. Kagda

Jennifer Jou

Otto Jolanki

Keenan Graham

Idan Gabdank

Shengcheng Dong

Eric Douglass

Beatrice Borsari

Pedro R. Assis

Kalina Andreeva

Mark B. Gerstein

J. Michael Cherry

Rico C. Ardy

Kaden M. Southard

Amit Lakhanpal

Laura T. Donlin

Norman M. Thomas

Melanie H. Smith

Vianne R. Gao

Preethi K. Periyakoil

Alexander Y. Rudensky

Yu Sun

Terence Li

Justin Langerman

Jason Ernst

Noah Zaitlen

Han Zhu

Kai Zhang

Nathan R. Zemke

Gaowei Wang

Mei-Lin Okino

Hannah Mummey

Adam Klie

Hannah S. Indralingam

Weronika Bartosik

Bing Ren

Kyle J. Gaulton

Maike Sander

Yunxiao Yang

Dapeng Yang

Jielin Yan

Breanna Williams

Xianming Wang

Thomas Vierbuchen

Simone Sidoli

Dustin Shigaki

Milad Razavi-Mohseni

Jin Woo Oh

Renhe Luo

Svetlana Jovanic

Nan Hu

David Godovich

Rachel A. Glenn

Ronald Cutler

Hyein Cho

Sharon Adeniyi

Anna-Katerina Hadjantonakis

Michael A. Beer

Zhijian Zhang

Hongjie Zhang

Wenli Yang

Qian Yang

Ning Xie

Sarah Tishkoff

Yijing Su

Junwei Shi

Qi Qiu

Kiran Musunuru

Guo-Li Ming

Dongming Liang

Fan Li

Julia I. Leu

Ronni Kurzion

Ziyue Gao

Jingli Cai

Hongjun Song

Sreeram Kannan

Hao Wu

Vivian F. Yi

Nicholas A. Pease

Daniel McGrail

Swapnil Keshari

Babita Kaundal

Abhinav K. Jain

Zarifeh H. Rarani

David R. Hall

Jingyu Fan

Trirupa Chakraborty

Deepa Bisht

Marisa Abundis

Austin T. Wang

Riya Sinha

Arpita Singhal

Jacob M. Schreiber

Kameron B. Rodrigues

Vivekanandan Ramalingam

Ivy Raine

Jonathan Pritchard

Aman Patel

Evin M. Padhi

AkshatKumar Nigam

Stephen B. Montgomery

Andrew R. Marderstein

Soumya Kundu

Eran Kotler

Livnat Jerby

Alexis Battle

Hufeng Zhou

Yi Zhang

Tianxiong Yu

Nicole Shedd

Shuo C. Shan

Nishigandha Phalke

Xihao Li

Natalie Haas

Yu Fu

Manuel Garber

Zhiping Weng

Yuriy Sverchkov

Robert D. Steiner

Eduardo Scopel

Michael Ohtake

Jiacheng Miao

Qiongshi Lu

Yiyang Jin

Kunling Huang

Audrey Gasch

Michelle Velyunskiy

M. Clara De Paolis Kaluza

Daniel Zeiberg

Shantanu Jain

Mariam Benazouz

Yile Chen

Tulika Kakati

Lilia M. Iakoucheva

Manolis Kellis

Arun Durvasula

Alkes Price

Soumya Raychaudhuri

Alexander Thomson

Boyao Li

Shengyu Li

Kuei-Yueh Ko

Raluca Gordan

Yuncheng Duan

Richard W. Doty

Shannon Clarke

C. David Page

Sayan Mukherjee

Nanxiang Zhao

Zhenhao Zhang

Joshua D. Welch

Yiqun Wang

Jinhao Wang

Rintsen N. Sherpa

Maureen A. Sartor

Tingting Qin

Weizhou Qian

Ryan E. Mills

Jie Liu

Linghua Jiang

Yuanhao Huang

Andre Guerra

Fan Feng

Elysia Chou

Christopher P. Castro

Ryan Weber

Sean Upchurch

Diane Trout

Nikki Swarna

Delaney K. Sullivan

Jasmine Sakr

Narges Rezaie

Elisabeth Rebboah

Angel G. Merchan

Grant MacGregor

Laura Luebbert

Rebekah Loving

Heidi Liang

Charlene Kim

Shimako Kawauchi

Kim Green

Ghassan Filibam

Dayeon Cheong

Maria Carilli

Barbara J. Wold

Wenxi Zhang

Yajie Yin

Chun J. Ye

Adam W. Turner

Katalin Sandor

Anita Qualls

Shreya Menon

Christopher S. McGinnis

Leif S. Ludwig

Vincent Liu

Caleb A. Lareau

Maya Kasowski

Lucas Kampman

Alia W. Johnson

Jacob C. Gutierrez

Zachary A. Gardell

James M. Gardner

Iris M. Chin

Serena H. Chang

M. Ryan Corces

Ansuman T. Satpathy

Wang Xi

Cassandra M. White

Siddarth Wekhande

Noam Shoresh

Mei K. Knudson

Alexandra M. Ham

Amelia W. Hall

Elizabeth Gaskell

Kaili Fan

Charles B. Epstein

Neva C. Durand

Fabiana M. Duarte

Kevin Dong

Guillermo Barreto Corona

Juliana Babu

Bradley E. Bernstein

Kari Strouse

Keith Siklenka

Helen L. Streff

Josephine C. Bodle

Maria A. ter Weele

Samuel J. Reisman

Christian D. McRoberts Amador

Sean R. McCutcheon

Siyan Liu

Marisa C. Hamilton

Lexi R. Bounds

Taylor Anglen

Boxun Li

Revathy Venukuttan

Ruhi Rai

Nahid Iglesias

William H. Majoros

Andrew S. Allen

Gregory E. Crawford

Charles A. Gersbach

Ting Wu

Marlena L. Starr

Jayoung Ryu

Quang Vinh Phan

Zain M. Patel

Zhijian Li

Estelle Lecluze

Benjamin P. Kleinstiver

Emily M. King

Nahye Kim

Ellie N. Gibbs

Matthew J. Francoeur

Eric Che

Logan J. Blaine

Basheer Becerra

Richard Sherwood

Guillaume Lettre

Daniel Bauer

Rachel A. Sharp

Sarah A. Schoenrock

Jonathan D. Rosen

Kimberly D. Ritola

Wancen Mu

Won Mah

Beverly H. Koller

Amy S. Etheridge

Katherine N. Degner

K. Alaine Broadaway

Jessica L. Bell

Hyejung Won

Qinbo Zhou

Huan Zhao

Yanfeng Zhang

Leqian Yu

Jian Xu

Lin Xu

Jun Wu

Yihan Wang

Lei Wang

Anjana Sundarrajan

Sushama Sivakumar

Daniel A. Schmitz

Bruce A. Posner

Carlos A. Pinzón-Arteaga

Mpathi Z. Nzima

Melissa K. McCoy

Hyung Bum Kim

Kiran Kaur

Sean C. Goetsch

Lauretta El Hayek

Ashlesha Gogate

Ashley E. Dederich

Daniel A. Armendariz

W. Lee Kraus

Zhipeng Yang

Anupama Yadav

Maxime Tixhon

Tanisha Teelucksingh

Mikko Taipale

Kerstin Spirohn-Fitzgerald

Shantanu Singh

Frederick P. Roth

Chloe Reno

Florent Laval

Jessica Lacoste

David E. Hill

Tong Hao

Marzieh Haghighi

Atina G. Coté

Georges Coppin

Beth A. Cimini

Zitong Sam Chen

Ronghao Zhou

Quanyi Zhao

Tony Zeng

David Yao

Fan Xia

Matthew D. Worssam

Chad S. Weldy

Anthony Venida

Alun Vaughan-Jackson

Mariëlle J. F. M. van Kooten

Valeh Valiollah Pour Amiri

Raeline C. Valbuena

Josh Tycko

Anthony Tan

Jason Tan

Lars M. Steinmetz

Vasundhara Singh

Huitong Shi

Maya U. Sheth

Disha Sharma

Gavin Schnitzler

Julia M. Schaepe

Oriane M. Rubio

Kevin R. Roy

Judhajeet Ray

Markus Ramste

Marlene Rabinovitch

Anusri Pampari

Brian T. Palmisano

Trieu Nguyen

Tri C. Nguyen

Glen Munson

Chad Munger

Kristy S. Mualim

Michael T. Montgomery

Joao P. Monteiro

Eyal Metzl-Raz

Chloe V. McCreery

Gabriella E. Martyn

Georgi K. Marinov

X. Rosa Ma

Dominik Lindenhofer

Daniel Y. Li

Roni Levin-Konigsberg

Yannick C. Lee-Yow

Mauro Lago-Docampo

Ramen Kundu

Sandy Klemm

YeEun Kim

Samuel H. Kim

Helen Y. Kang

Hank Jones

Nimit Jain

Evelyn Jagoda

Sarasa Isobe

Revant Gupta

Katherine Guo

William J. Greenleaf

Casey Gifford

James A. Galante

Peter P. Du

Benjamin R. Doughty

Salil Deshpande

Stephanie Conley

Ziwei Chen

Xiangmeng Shawn Cai

Asmita Bhattacharya

Julia R. Bauman

Michael C. Bassik

Sophia M. Arana

Aradhana Aradhana

Dulguun Amgalan

Brendan D. Zapp

Ivan Woo

Melinda K. Wheelock

Ziyu R. Wang

Malvika Tejura

Jeremy Stone

Nahum T. Smith

Alan F. Rubin

Mason Post

Nicholas A. Popp

Sriram Pendyala

Nick Moore

Abbye E. McEwen

Gail P. Jarvik

Richard G. James

Audrey Hamm

Shawn Fayer

Samantha C. Dawson

Moez Dawood

Estelle Y. Da

Silvia Casadei

Nathan Camp

Gabe Boyle

Sabrina M. Best

Aki Ushiki

Jasmine Sims

Sam Regalado

Nicholas F. Page

Mai Nobuhara

Troy A. McDiarmid

Beth Martin

Thorben Maass

Jean-Benoît Lalanne

Connor Kubo

Pia Keukeleire

Nobuhiko Hamazaki

Chengyu Deng

Pyaree M. Dash

Florence M. Chardon

Theofilos Chalkiadakis

Andrew Blair

Vikram Agarwal

Jay Shendure

Lior Pachter

Surag Nair

Eugenio Mattei

Sina Booeshaghi

Saori Sakaue

Ingileif Hallgrimsdottir

S. Stephen Yi

Nadav Ahituv

Jill E. Moore

Andreas R. Gschwind

Max Schubach

Alejandro Barrera

Kathrin Plath

Chongyuan Luo

Stefanija Giric

Rachel E. Savage

Christina S. Leslie

Jason D. Buenrostro

Anne E. Carpenter

Shamil Sunyaev

Steven K. Reilly

Evan Koch

Steven Gazal

Jingjing Zhao

Vikas Pejaver

Sean D. Mooney

Lucas Ferreira

Marc Vidal

Douglas M. Fowler

Michael A. Calderwood

Jishnu Das

Thomas Quertermous

Chong Y. Park

Danwei Huangfu

Brian A. Williams

Brunilda Balliu

Predrag Radivojac

Jian Ma

Martin Kircher

Eric Van Buren

Fairlie Reese

Michael J. Pazin

Lara A. Muffley

Michael I. Love

Nina P. Farrell

Sarah Cody

Feng Yue

Anshul Kundaje

Ting Wang

Luca Pinello

Karen L. Mohlke

Mark Craven

Ali Mortazavi

Benjamin C. Hitz

Alan P. Boyle

Maria H. Chahrour

Nikhil V. Munshi

Yun Li

Xihong Lin

Timothy E. Reddy

Nidhi Sahni

Hannah Carter

Gary C. Hon

Lea M. Starita

Harinder Singh

Heather A. Lawson

Jesse M. Engreitz

Affiliated Authors: