Nimbolide targets RNF114 to induce the trapping of PARP1 and synthetic lethality in BRCA-mutated cancer

Li, P., Zhen, Y., Kim, C., Liu, Z., Hao, J., Deng, H., Deng, H., Zhou, M., Wang, X.-D., Qin, T., & Yu, Y. (2023). Nimbolide targets RNF114 to induce the trapping of PARP1 and synthetic lethality in BRCA -mutated cancer. Science Advances, 9(43). https://doi.org/10.1126/sciadv.adg7752

Authors:

Peng Li

Yuanli Zhen

Chiho Kim

Zhengshuai Liu

Jianwei Hao

Heping Deng

Hejun Deng

Min Zhou

Xu-Dong Wang

Tian Qin

Yonghao Yu

Affiliated Authors:

Chiho Kim

Zhengshuai Liu

Jianwei Hao

Xu-Dong Wang

Yonghao Yu

Columbia Affiliation:

Vagelos College of Physicians and Surgeons
- Department of Molecular Pharmacology and Therapeutics

Subjects:

Synthetic Lethal Mutations (MeSH)

Neoplasms (MeSH)

Publication Type:

Article

Unique ID:

10.1126/sciadv.adg7752

PMID:

DOI:

10.1126/sciadv.adg7752

Journal:

Science Advances

Publication Date:

2023-10-25

Data Source:

PubMed

Source Link:

View PubMed Record

View Scopus Record

Record Created:

Monday, August 5, 2024 - 11:38