Safety, tolerability, pharmacokinetics, and immunological activity of dual-combinations and triple-combinations of anti-HIV monoclonal antibodies PGT121, PGDM1400, 10-1074, and VRC07-523LS administered intravenously to HIV-uninfected adults: a phase 1 randomised trial

Sobieszczyk, M. E., Mannheimer, S., Paez, C. A., Yu, C., Gamble, T., Theodore, D. A., Chege, W., Yacovone, M., Hanscom, B., Heptinstall, J., Seaton, K. E., Zhang, L., Miner, M. D., Eaton, A., Weiner, J. A., Mayer, K., Kalams, S., Stephenson, K., Julg, B., … Montefiori, D. (2023). Safety, tolerability, pharmacokinetics, and immunological activity of dual-combinations and triple-combinations of anti-HIV monoclonal antibodies PGT121, PGDM1400, 10-1074, and VRC07-523LS administered intravenously to HIV-uninfected adults: a phase 1 randomised trial. The Lancet HIV, 10(10), e653–e662. https://doi.org/10.1016/s2352-3018(23)00140-6
Authors:
Magdalena E Sobieszczyk
Sharon Mannheimer
Carmen A Paez
Chenchen Yu
Theresa Gamble
Deborah A Theodore
Wairimu Chege
Margaret Yacovone
Brett Hanscom
Jack Heptinstall
Kelly E Seaton
Lily Zhang
Maurine D Miner
Amanda Eaton
Joshua A Weiner
Kenneth Mayer
Spyros Kalams
Kathryn Stephenson
Boris Julg
Marina Caskey
Michel Nussenzweig
Lucio Gama
Dan H Barouch
Margaret E Ackerman
Georgia D Tomaras
Yunda Huang
David Montefiori
Affiliated Authors:
Magdalena E Sobieszczyk
Sharon Mannheimer
Deborah A Theodore
Subjects:
HIV-1 (MeSH)
Publication Type:
Article
Unique ID:
10.1016/s2352-3018(23)00140-6
PMID:
Journal:
Publication Date:
Data Source:
PubMed

Record Created: