Meta-analyses of mouse and human prostate single-cell transcriptomes reveal widespread epithelial plasticity in tissue regression, regeneration, and cancer

Aparicio, L., Crowley, L., Christin, J. R., Laplaca, C. J., Hibshoosh, H., Rabadan, R., & Shen, M. M. (2025). Meta-analyses of mouse and human prostate single-cell transcriptomes reveal widespread epithelial plasticity in tissue regression, regeneration, and cancer. Genome Medicine, 17(1). https://doi.org/10.1186/s13073-025-01432-w
Authors:
Luis Aparicio
Laura Crowley
John R Christin
Caroline J Laplaca
Hanina Hibshoosh
Raul Rabadan
Michael M Shen
Affiliated Authors:
Luis Aparicio
Laura Crowley
John R Christin
Caroline J Laplaca
Hanina Hibshoosh
Raul Rabadan
Michael M Shen
Columbia Affiliation:
Subjects:
Single-Cell Analysis (MeSH)
Prostatic Neoplasms (MeSH)
Prostate (MeSH)
Epithelial Cells (MeSH)
Transcriptome (MeSH)
Regeneration (MeSH)
Cell Plasticity (MeSH)
Author Keywords:
prostate cancer
scrna-seq
tumor heterogeneity
plasticity
castration
androgen receptor
field cancerization
elink
Publication Type:
Article
Unique ID:
10.1186/s13073-025-01432-w
PMID:
39825401
DOI:
10.1186/s13073-025-01432-w
Journal:
Genome Medicine
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record
View Web of Science Record

Record Created: