The case-only design is a powerful approach to detect interactions but should be used with caution

Dong, R., Wang, G. T., DeWan, A. T., & Leal, S. M. (2025). The case-only design is a powerful approach to detect interactions but should be used with caution. BMC Genomics, 26(1). https://doi.org/10.1186/s12864-025-11318-1
Authors:
Rui Dong
Gao T Wang
Andrew T DeWan
Suzanne M Leal
Affiliated Authors:
Rui Dong
Gao T Wang
Suzanne M Leal
Columbia Affiliation:
Subjects:
Genomic Studies and Association Analyses (OpenAlex Topic)
Genomic Rearrangements and Copy Number Variations (OpenAlex Topic)
Genetic Research on BRCA Mutations and Cancer Risk (OpenAlex Topic)
Gene-Environment Interaction (MeSH)
Author Keywords:
case-only design
complex traits
gene x gene and gene x environment interactions
rare disease
gene <br />
×<br />
gene and gene <br />
×<br />
environment interactions
elink
Publication Type:
Article
Unique ID:
10.1186/s12864-025-11318-1
PMID:
40050722
DOI:
10.1186/s12864-025-11318-1
Journal:
BMC Genomics
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record
View OpenAlex Record
View Web of Science Record

Record Created: