Small-molecule antagonism of the interaction of the RAGE cytoplasmic domain with DIAPH1 reduces diabetic complications in mice

Manigrasso, M. B., Rabbani, P., Egaña-Gorroño, L., Quadri, N., Frye, L., Zhou, B., Reverdatto, S., Ramirez, L. S., Dansereau, S., Pan, J., Li, H., D’Agati, V. D., Ramasamy, R., DeVita, R. J., Shekhtman, A., & Schmidt, A. M. (2021). Small-molecule antagonism of the interaction of the RAGE cytoplasmic domain with DIAPH1 reduces diabetic complications in mice. Science Translational Medicine, 13(621). https://doi.org/10.1126/scitranslmed.abf7084

Authors:

Michaele B Manigrasso

Piul Rabbani

Lander Egaña-Gorroño

Nosirudeen Quadri

Laura Frye

Boyan Zhou

Sergey Reverdatto

Lisa S Ramirez

Stephen Dansereau

Jinhong Pan

Huilin Li