Ancestry adjustment improves genome-wide estimates of regional intolerance

Hayeck, T. J., Stong, N., Baugh, E., Dhindsa, R., Turner, T. N., Malakar, A., Mosbruger, T. L., Shaw, G. T.-W., Duan, Y., Ionita-Laza, I., Goldstein, D., & Allen, A. S. (2022). Ancestry adjustment improves genome-wide estimates of regional intolerance. Genetics. https://doi.org/10.1093/genetics/iyac050
Authors:
Tristan J. Hayeck
Nicholas Stong
Evan Baugh
Ryan Dhindsa
Tychele N. Turner
Ayan Malakar
Timothy L. Mosbruger
Grace Tzun-Wen Shaw
Yuncheng Duan
Iuliana Ionita-Laza
David Goldstein
Andrew S. Allen
Affiliated Authors:
Nicholas Stong
Evan Baugh
Ryan Dhindsa
Ayan Malakar
Iuliana Ionita-Laza
David Goldstein
Columbia Affiliation:
Subjects:
Genome, Human (MeSH)
Genomics (MeSH)
RNA Sequencing Data Analysis (OpenAlex Topic)
Evolutionary Dynamics of Genetic Adaptation and Mutation (OpenAlex Topic)
Standards and Guidelines for Genetic Variant Interpretation (OpenAlex Topic)
Author Keywords:
statistical genetics
population genetics
evolution
genetic epidemiology
negative selection
genetic intolerance
intolerance to variation
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Publication Type:
Article
Unique ID:
10.1093/genetics/iyac050
PMID:
35385101
DOI:
10.1093/genetics/iyac050
Journal:
Genetics
Publication Date:
Data Source:
Scopus
Source Link:
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Record Created: