Trapping of spermine, Kukoamine A, and polyamine toxin blockers in GluK2 kainate receptor channels

Gangwar, S. P., Yelshanskaya, M. V., Aktolun, M., Yen, L. Y., Newton, T. P., Strømgaard, K., Kurnikova, M. G., & Sobolevsky, A. I. (2024). Trapping of spermine, Kukoamine A, and polyamine toxin blockers in GluK2 kainate receptor channels. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-54538-x
Authors:
Shanti Pal Gangwar
Maria V Yelshanskaya
Muhammed Aktolun
Laura Y Yen
Thomas P Newton
Kristian Strømgaard
Maria G Kurnikova
Alexander I Sobolevsky
Affiliated Authors:
Shanti Pal Gangwar
Maria V Yelshanskaya
Laura Y Yen
Thomas P Newton
Alexander I Sobolevsky
Columbia Affiliation:
Subjects:
Spermine (MeSH)
Receptors, Kainic Acid (MeSH)
GluK2 Kainate Receptor (MeSH)
Molecular Dynamics Simulation (MeSH)
Grants:
R01CA206573 (NIH – National Cancer Institute)
R01AR078814 (NIH – National Institute of Arthritis and Musculoskeletal and Skin Diseases)
U24GM129539 (NIH – National Institute of General Medical Sciences)
U24GM129547 (NIH – National Institute of General Medical Sciences)
U24GM129541 (NIH – National Institute of General Medical Sciences)
R01NS107253 (NIH – National Institute of Neurological Disorders and Stroke)
R37NS083660 (NIH – National Institute of Neurological Disorders and Stroke)
R01NS083660 (NIH – National Institute of Neurological Disorders and Stroke)
R21NS139087 (NIH – National Institute of Neurological Disorders and Stroke)
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Publication Type:
Article
Unique ID:
10.1038/s41467-024-54538-x
PMID:
39592599
DOI:
10.1038/s41467-024-54538-x
Journal:
Nature Communications
Publication Date:
Data Source:
PubMed
Source Link:
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