In Vitro Functional Profiling of Fentanyl and Nitazene Analogs at the μ-Opioid Receptor Reveals High Efficacy for Gi Protein Signaling

Tsai, M.-H. M., Chen, L., Baumann, M. H., Canals, M., Javitch, J. A., Lane, J. R., & Shi, L. (2024). In Vitro Functional Profiling of Fentanyl and Nitazene Analogs at the μ-Opioid Receptor Reveals High Efficacy for Gi Protein Signaling. ACS Chemical Neuroscience, 15(4), 854–867. https://doi.org/10.1021/acschemneuro.3c00750
Authors:
Meng-Hua M Tsai
Li Chen
Michael H Baumann
Meritxell Canals
Jonathan A Javitch
J Robert Lane
Lei Shi
Affiliated Authors:
Jonathan A Javitch
Subjects:
Author Keywords:
fentanyl
nitazene
mu-opioid receptor
functional assay
intrinsic efficacy
transductioncoefficient
transduction coefficient
μ-opioid receptor
Publication Type:
Article
Unique ID:
10.1021/acschemneuro.3c00750
PMID:
Publication Date:
Data Source:
PubMed

Record Created: