Fixed dosing versus weight-based dosing of HIV-1 prophylactic monoclonal antibodies in adults: a post-hoc, cross-protocol pharmacokinetics modelling study

Huang, Y., Zhang, L., Gelderblom, H., Seaton, K. E., Yates, N. L., Paez, C. A., Karuna, S. T., Andrew, P., Gamble, T., Robinson, S. T., Ledgerwood, J. E., Hyrien, O., Walsh, S. R., Gay, C. L., Gwira, J. A., Spiegel, H. M. L., Sobieszczyk, M. E., Mannheimer, S. B., Edupuganti, S., … Stein, J. (2025). Fixed dosing versus weight-based dosing of HIV-1 prophylactic monoclonal antibodies in adults: a post-hoc, cross-protocol pharmacokinetics modelling study. EBioMedicine, 117, 105804. https://doi.org/10.1016/j.ebiom.2025.105804
Authors:
Yunda Huang
Lily Zhang
Huub Gelderblom
Kelly E Seaton
Nicole L Yates
Carmen A Paez
Shelly T Karuna
Philip Andrew
Theresa Gamble
Samuel T Robinson
Julie E Ledgerwood
Ollivier Hyrien
Stephen R Walsh
Cynthia L Gay
Jane A Gwira
Hans M L Spiegel
Magdalena E Sobieszczyk
Sharon B Mannheimer
Srilatha Edupuganti
Christopher B Hurt
Kathryn E Stephenson
Chenchen Yu
Colleen F Kelley
Sharana Mahomed
Marc Siegel
Margaret Yacovone
Michael N Pensiero
Deborah Donnell
Myron S Cohen
Lawrence Corey
Peter B Gilbert
Richard A Koup
Georgia D Tomaras
Affiliated Authors:
Magdalena E Sobieszczyk
Sharon B Mannheimer
Columbia Affiliation:
Author Keywords:
dosing strategy
exponent of body weight
hiv prevention
population pharmacokinetics model
two-compartment
variability in exposure
elink
Publication Type:
Article
Unique ID:
10.1016/j.ebiom.2025.105804
PMID:
40516378
DOI:
10.1016/j.ebiom.2025.105804
Journal:
EBioMedicine
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record

Record Created: