Sequential activation of E2F via Rb degradation and c-Myc drives resistance to CDK4/6 inhibitors in breast cancer

Kim, S., Armand, J., Safonov, A., Zhang, M., Soni, R. K., Schwartz, G., McGuinness, J. E., Hibshoosh, H., Razavi, P., Kim, M., Chandarlapaty, S., & Yang, H. W. (2023). Sequential activation of E2F via Rb degradation and c-Myc drives resistance to CDK4/6 inhibitors in breast cancer. Cell Reports, 42(11), 113198. https://doi.org/10.1016/j.celrep.2023.113198
Authors:
Sung Soo Kim
Jessica Armand
Anton Safonov
Mimi Zhang
Rajesh K. Soni
Gary K. Schwartz
Julia E. McGuinness
Hanina Hibshoosh
Pedram Razavi
Minah Kim
Sarat Chandarlapaty
Hee Won Yang
Affiliated Authors:
Sung Soo Kim
Jessica Armand
Mimi Zhang
Rajesh K. Soni
Gary K. Schwartz
Julia E. McGuinness
Hanina Hibshoosh
Minah Kim
Hee Won Yang
Columbia Affiliation:
Subjects:
Breast Neoplasms (MeSH)
Retinoblastoma (MeSH)
Retinal Neoplasms (MeSH)
Cyclin-Dependent Kinase 4/6 Inhibitors in Breast Cancer (OpenAlex Topic)
The p53 Signaling Network in Cancer Research (OpenAlex Topic)
Genomic Aberrations and Treatment of Chronic Lymphocytic Leukemia (OpenAlex Topic)
Author Keywords:
breast cancer
cdk4/6 inhibitors
cp: cancer
drug resistance
e2f transcription factors
retinoblastoma protein
elink
Publication Type:
Article
Unique ID:
10.1016/j.celrep.2023.113198
PMID:
37865915
DOI:
10.1016/j.celrep.2023.113198
Journal:
Cell Reports
Publication Date:
Data Source:
OpenAlex
Source Link:
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