Optimizing metabolic stability of phosphodiesterase 5 inhibitors: Discovery of a potent N-(pyridin-3-ylmethyl)quinoline derivative targeting synaptic plasticity

Zuccarello, E., Zhang, H., Acquarone, E., Pham, D., Staniszewski, A., Deng, S.-X., Landry, D. W., Arancio, O., & Fiorito, J. (2023). Optimizing metabolic stability of phosphodiesterase 5 inhibitors: Discovery of a potent N-(pyridin-3-ylmethyl)quinoline derivative targeting synaptic plasticity. Bioorganic & Medicinal Chemistry Letters, 92, 129409. https://doi.org/10.1016/j.bmcl.2023.129409
Authors:
Elisa Zuccarello
Hong Zhang
Erica Acquarone
Dang Pham
Anna Staniszewski
Shi-Xian Deng
Donald W Landry
Ottavio Arancio
Jole Fiorito
Affiliated Authors:
Elisa Zuccarello
Hong Zhang
Erica Acquarone
Anna Staniszewski
Shi-Xian Deng
Donald W Landry
Ottavio Arancio
Jole Fiorito
Subjects:
Author Keywords:
cgmp
human liver microsomes
metabolic stability
pde5 inhibitors
quinoline derivatives
tau protein
Publication Type:
Article
Unique ID:
10.1016/j.bmcl.2023.129409
PMID:
Publication Date:
Data Source:
PubMed

Record Created: