Novel dual-lumen microneedle delivers adeno-associated viral vectors in the guinea pig inner ear via the round window membrane

Hammer, D. R., Voruz, F., Aksit, A., Breil, E., Rousset, F., Senn, P., Ilmjärv, S., Olson, E. S., Lalwani, A. K., & Kysar, J. W. (2025). Novel dual-lumen microneedle delivers adeno-associated viral vectors in the guinea pig inner ear via the round window membrane. Biomedical Microdevices, 27(2). https://doi.org/10.1007/s10544-025-00751-4
Authors:
Daniella R Hammer
François Voruz
Aykut Aksit
Eugénie Breil
Francis Rousset
Pascal Senn
Sten Ilmjärv
Elizabeth S Olson
Anil K Lalwani
Jeffrey W Kysar
Affiliated Authors:
François Voruz
Eugénie Breil
Elizabeth S Olson
Anil K Lalwani
Jeffrey W Kysar
Columbia Affiliation:
Subjects:
Dependovirus (MeSH)
Needles (MeSH)
Genetic Vectors (MeSH)
Round Window, Ear (MeSH)
Ear, Inner (MeSH)
Gene Transfer Techniques (MeSH)
Author Keywords:
adeno-associated virus (aav)
gene therapy
hearing
inner ear drug delivery
microneedle
round window membrane
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Publication Type:
Article
Unique ID:
10.1007/s10544-025-00751-4
PMID:
40493265
DOI:
10.1007/s10544-025-00751-4
Journal:
Biomedical Microdevices
Publication Date:
Data Source:
PubMed
Source Link:
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Record Created: