REV1-Polζ maintains the viability of homologous recombination-deficient cancer cells through mutagenic repair of PRIMPOL-dependent ssDNA gaps

Taglialatela, A., Leuzzi, G., Sannino, V., Cuella-Martin, R., Huang, J.-W., Wu-Baer, F., Baer, R., Costanzo, V., & Ciccia, A. (2021). REV1-Polζ maintains the viability of homologous recombination-deficient cancer cells through mutagenic repair of PRIMPOL-dependent ssDNA gaps. Molecular Cell, 81(19), 4008-4025.e7. https://doi.org/10.1016/j.molcel.2021.08.016
Authors:
Angelo Taglialatela
Giuseppe Leuzzi
Vincenzo Sannino
Raquel Cuella-Martin
Jen-Wei Huang
Foon Wu-Baer
Richard Baer
Vincenzo Costanzo
Alberto Ciccia
Affiliated Authors:
Angelo Taglialatela
Giuseppe Leuzzi
Raquel Cuella-Martin
Jen-Wei Huang
Foon Wu-Baer
Richard Baer
Alberto Ciccia
Columbia Affiliation:
Author Keywords:
brca1 and brca2
breast and ovarian cancer
dna repriming
homologous recombination
primpol
rad18
rev1 and polζ
ssdna gaps
synthetic lethality
translesion synthesis
elink
Publication Type:
Article
Unique ID:
10.1016/j.molcel.2021.08.016
PMID:
34508659
DOI:
10.1016/j.molcel.2021.08.016
Journal:
Molecular Cell
Publication Date:
Data Source:
Scopus
Source Link:
View Scopus Record
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Record Created: