hPSC-derived sacral neural crest enables rescue in a severe model of Hirschsprung's disease

Fan, Y., Hackland, J., Baggiolini, A., Hung, L. Y., Zhao, H., Zumbo, P., Oberst, P., Minotti, A. P., Hergenreder, E., Najjar, S., Huang, Z., Cruz, N. M., Zhong, A., Sidharta, M., Zhou, T., de Stanchina, E., Betel, D., White, R. M., Gershon, M., … Studer, L. (2023). hPSC-derived sacral neural crest enables rescue in a severe model of Hirschsprung’s disease. Cell Stem Cell, 30(3), 264-282.e9. https://doi.org/10.1016/j.stem.2023.02.003
Authors:
Yujie Fan
James Hackland
Arianna Baggiolini
Lin Y. Hung
Huiyong Zhao
Paul Zumbo
Polina Oberst
Andrew P. Minotti
Emiliano Hergenreder
Sarah Najjar
Zixing Huang
Nelly M. Cruz
Aaron Zhong
Mega Sidharta
Ting Zhou
Elisa de Stanchina
Doron Betel
Richard M. White
Michael Gershon
Kara Gross Margolis
Lorenz Studer
Affiliated Authors:
Michael Gershon
Author Keywords:
axial patterning
axial progenitors
cell therapy
directed differentiation
enteric nervous system
gdf11
hirschsprung's disease
nervous system disorder
neural crest development
pluripotent stem cells
regenerative medicine
sacral neural crest
Publication Type:
Article
Unique ID:
10.1016/j.stem.2023.02.003
PMID:
Journal:
Publication Date:
Data Source:
Scopus

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