Large-scale copy number alterations are enriched for synthetic viability in BRCA1/BRCA2 tumors

Zhu, Y., Pei, X., Novaj, A., Setton, J., Bronder, D., Derakhshan, F., Selenica, P., McDermott, N., Orman, M., Plum, S., Subramanyan, S., Braverman, S. H., McMillan, B., Sinha, S., Ma, J., Gazzo, A., Khan, A., Bakhoum, S., Powell, S. N., … Riaz, N. (2024). Large-scale copy number alterations are enriched for synthetic viability in BRCA1/BRCA2 tumors. Genome Medicine, 16(1). https://doi.org/10.1186/s13073-024-01371-y
Authors:
Yingjie Zhu
Xin Pei
Ardijana Novaj
Jeremy Setton
Daniel Bronder
Fatemeh Derakhshan
Pier Selenica
Niamh McDermott
Mehmet Orman
Sarina Plum
Shyamal Subramanyan
Sara H Braverman
Biko McMillan
Sonali Sinha
Jennifer Ma
Andrea Gazzo
Atif Khan
Samuel Bakhoum
Simon N Powell
Jorge S Reis-Filho
Nadeem Riaz
Affiliated Authors:
Fatemeh Derakhshan
Author Keywords:
brca1
brca2
copy number alterations
crispr-cas9 knockout
dna repair
gene expression
icgc
synthetic viability
tcga
Publication Type:
Article
Unique ID:
10.1186/s13073-024-01371-y
PMID:
Journal:
Publication Date:
Data Source:
PubMed

Record Created: