TRLS-07. PNOC016: INTRATUMORAL PHARMACOKINETICS AND PHARMACODYNAMIC (PK/PD) RESULTS FROM A TARGET VALIDATION STUDY OF A NOVEL PAN-HDAC AND PI3K INHIBITOR, FIMEPINOSTAT, IN CHILDREN AND YOUNG ADULTS WITH NEWLY DIAGNOSED DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG), RECURRENT MEDULLOBLASTOMA (MB), AND RECURRENT HIGH-GRADE GLIOMA (HGG)

Kline, C., Crawford, J. R., Reddy, A. T., Gerber, N., Stucklin, A. G., Kilburn, L., Packer, R., Margol, A., Crotty, E., Sayour, E., Franson, A., Phillips, J., Singh, S., Hamanishi, E., Lee, C., Bhatia, A., George, E., Rauschecker, A., Molinaro, A., … Mueller, S. (2024). TRLS-07. PNOC016: INTRATUMORAL PHARMACOKINETICS AND PHARMACODYNAMIC (PK/PD) RESULTS FROM A TARGET VALIDATION STUDY OF A NOVEL PAN-HDAC AND PI3K INHIBITOR, FIMEPINOSTAT, IN CHILDREN AND YOUNG ADULTS WITH NEWLY DIAGNOSED DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG), RECURRENT MEDULLOBLASTOMA (MB), AND RECURRENT HIGH-GRADE GLIOMA (HGG). Neuro-Oncology, 26(Supplement_4), 0–0. https://doi.org/10.1093/neuonc/noae064.160
Authors:
Cassie Kline
John R. Crawford
Alyssa Reddy
Nicolas U. Gerber
Ana Guerreiro Stücklin
Lindsay Kilburn
Roger J. Packer
Ashley Margol
Erin E. Crotty
Elias Sayour
Andrea Franson
Joanna J. Phillips
Shefali Singh
Erin Hamanishi
Christopher Lee
Aashim Bhatia
Elizabeth George
Andreas M. Rauschecker
Annette M. Molinaro
Michael Prados
Javad Nazarian
Sriram Venneti
Robert J. Wechsler‐Reya
Sabine Mueller
Affiliated Authors:
Robert J. Wechsler‐Reya
Subjects:
Gliomas (OpenAlex Topic)
Targeted Protein Degradation in Biomedical Research (OpenAlex Topic)
Poly(ADP-ribose) Polymerase Inhibition in Cancer Therapy (OpenAlex Topic)
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Publication Type:
Article
Unique ID:
10.1093/neuonc/noae064.160
DOI:
10.1093/neuonc/noae064.160
Journal:
Neuro-Oncology
Publication Date:
Data Source:
OpenAlex
Source Link:
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