Multi-node inhibition targeting mTORC1, mTORC2 and PI3Kα potently inhibits the PI3K/AKT/mTOR pathway in endometrial and breast cancer models

Tyrakis, P. A., Kampjut, D., Steele, G. F., Lindström, H. J. G., Chirnomas, D., Hopkins, B. D., Goncalves, M. D., Mukherjee, S., Cantley, L. C., & Maddocks, O. D. K. (2025). Multi-node inhibition targeting mTORC1, mTORC2 and PI3Kα potently inhibits the PI3K/AKT/mTOR pathway in endometrial and breast cancer models. British Journal of Cancer. https://doi.org/10.1038/s41416-025-03035-z

Authors:

Petros A Tyrakis

Domen Kampjut

Georgina F Steele

H Jonathan G Lindström

Deborah Chirnomas

Benjamin D Hopkins

Marcus D Goncalves

Siddhartha Mukherjee

Lewis C Cantley

Oliver D K Maddocks

Affiliated Authors: