Safety and efficacy of long-term gantenerumab treatment in dominantly inherited Alzheimer's disease: an open-label extension of the phase 2/3 multicentre, randomised, double-blind, placebo-controlled platform DIAN-TU trial

Bateman, R. J., Li, Y., McDade, E. M., Llibre-Guerra, J. J., Clifford, D. B., Atri, A., Mills, S. L., Santacruz, A. M., Wang, G., Supnet, C., Benzinger, T. L. S., Gordon, B. A., Ibanez, L., Klein, G., Baudler, M., Doody, R. S., Delmar, P., Kerchner, G. A., Bittner, T., … Schofield, P. R. (2025). Safety and efficacy of long-term gantenerumab treatment in dominantly inherited Alzheimer’s disease: an open-label extension of the phase 2/3 multicentre, randomised, double-blind, placebo-controlled platform DIAN-TU trial. The Lancet Neurology, 24(4), 316–330. https://doi.org/10.1016/s1474-4422(25)00024-9
Authors:
Randall J Bateman
Yan Li
Eric M McDade
Jorge J Llibre-Guerra
David B Clifford
Alireza Atri
Susan L Mills
Anna M Santacruz
Guoqiao Wang
Charlene Supnet
Tammie L S Benzinger
Brian A Gordon
Laura Ibanez
Gregory Klein
Monika Baudler
Rachelle S Doody
Paul Delmar
Geoffrey A Kerchner
Tobias Bittner
Jakub Wojtowicz
Azad Bonni
Paulo Fontoura
Carsten Hofmann
Luka Kulic
Jason Hassenstab
Andrew J Aschenbrenner
Richard J Perrin
Carlos Cruchaga
Alan E Renton
Chengjie Xiong
Alison A Goate
John C Morris
David M Holtzman
B Joy Snider
Catherine Mummery
William S Brooks
David Wallon
Sarah B Berman
Erik Roberson
Colin L Masters
Douglas R Galasko
Suman Jayadev
Rachel Sanchez-Valle
Jeremie Pariente
Justin Kinsella
Christopher H van Dyck
Serge Gauthier
Ging-Yuek Robin Hsiung
Mario Masellis
Bruno Dubois
Lawrence S Honig
Clifford R Jack
Alisha Daniels
David Aguillón
Ricardo Allegri
Jasmeer Chhatwal
Gregory Day
Nick C Fox
Edward Huey
Takeshi Ikeuchi
Mathias Jucker
Jae-Hong Lee
Allan I Levey
Johannes Levin
Francisco Lopera
JeeHoon Roh
Pedro Rosa-Neto
Peter R Schofield
Affiliated Authors:
Lawrence S Honig
Columbia Affiliation:
Subjects:
Antibodies, Monoclonal, Humanized (MeSH)
Alzheimer Disease (MeSH)
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Publication Type:
Article
Unique ID:
10.1016/s1474-4422(25)00024-9
PMID:
40120616
DOI:
10.1016/s1474-4422(25)00024-9
Journal:
Lancet Neurology
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record

Record Created: