Intranasal oxytocin for apathy in people with frontotemporal dementia (FOXY): a multicentre, randomised, double-blind, placebo-controlled, adaptive, crossover, phase 2a/2b superiority trial

Coleman, K. K. L., Berry, S., Cummings, J., Hsiung, G.-Y. R., Laforce, R., Huey, E., Ducharme, S., Tartaglia, M. C., Mendez, M. F., Onyike, C., Domoto-Reilly, K., Masellis, M., Herrmann, N., Porsteinsson, A., Detry, M. A., Stewart, C., Bosse, A. L., McGlothlin, A., Dias, B., … Finger, E. C. (2025). Intranasal oxytocin for apathy in people with frontotemporal dementia (FOXY): a multicentre, randomised, double-blind, placebo-controlled, adaptive, crossover, phase 2a/2b superiority trial. The Lancet Neurology, 24(2), 128–139. https://doi.org/10.1016/s1474-4422(24)00456-3
Authors:
Kristy K L Coleman
Scott Berry
Jeffrey Cummings
Ging-Yuek R Hsiung
Robert Laforce
Edward Huey
Simon Ducharme
Maria Carmela Tartaglia
Mario F Mendez
Chiadi Onyike
Kimiko Domoto-Reilly
Mario Masellis
Nathan Herrmann
Anton Porsteinsson
Michelle A Detry
Chloe Stewart
Anna L Bosse
Anna McGlothlin
Bryan Dias
Sachin Pandey
Michael Mayich
Stephen H Pasternak
Ramiro Ruiz Garcia
Miguel Restrepo-Martinez
Howard Feldman
Adam L Boxer
Elizabeth C Finger
Affiliated Authors:
Edward Huey
Columbia Affiliation:
Subjects:
Administration, Intranasal (MeSH)
Apathy (MeSH)
Oxytocin (MeSH)
Cross-Over Studies (MeSH)
Frontotemporal Dementia (MeSH)
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Publication Type:
Article
Unique ID:
10.1016/s1474-4422(24)00456-3
PMID:
39862881
DOI:
10.1016/s1474-4422(24)00456-3
Journal:
Lancet Neurology
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record
View Scopus Record

Record Created: