CRISPR editing of anti-anemia drug target rescues independent preclinical models of retinitis pigmentosa

Nolan, N. D., Cui, X., Robbings, B. M., Demirkol, A., Pandey, K., Wu, W.-H., Hu, H. F., Jenny, L. A., Lin, C.-S., Hass, D. T., Du, J., Hurley, J. B., & Tsang, S. H. (2024). CRISPR editing of anti-anemia drug target rescues independent preclinical models of retinitis pigmentosa. Cell Reports Medicine, 5(4), 101459. https://doi.org/10.1016/j.xcrm.2024.101459

Authors:

Nicholas D Nolan

Xuan Cui

Brian M Robbings

Aykut Demirkol

Kriti Pandey

Wen-Hsuan Wu

Hannah F Hu

Laura A Jenny

Chyuan-Sheng Lin

Daniel T Hass

Jianhai Du

James B Hurley

Stephen H Tsang

Affiliated Authors:

Nicholas D Nolan

Xuan Cui

Aykut Demirkol

Wen-Hsuan Wu

Hannah F Hu

Laura A Jenny

Chyuan-Sheng Lin

Stephen H Tsang

Columbia Affiliation:

Subjects:

Molecular Mechanisms of Retinal Degeneration and Regeneration (OpenAlex Topic)

Clustered Regularly Interspaced Short Palindromic Repeats and CRISPR-associated proteins (OpenAlex Topic)

Optogenetics in Neuroscience and Biophysics Research (OpenAlex Topic)

Retinal Rod Photoreceptor Cells (MeSH)

Retinitis Pigmentosa (MeSH)

Author Keywords:

aav

crispr

gene therapy

glycolysis

hypoxia inducible factor

metabolic reprogramming

prolyl hydroxylase

rejuvenation

retinal degeneration

therapeutic editing

Publication Type:

Article

Unique ID:

10.1016/j.xcrm.2024.101459

PMID:

DOI:

10.1016/j.xcrm.2024.101459

Journal:

Cell Reports Medicine

Publication Date:

2024-03-21

Data Source:

PubMed

Source Link:

View PubMed Record

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Record Created:

Sunday, July 28, 2024 - 20:54