A selective small-molecule agonist of G protein-gated inwardly-rectifying potassium channels reduces epileptiform activity in mouse models of tumor-associated and provoked seizures

Rifkin, R. A., Wu, X., Pereira, B., Gill, B. JA., Merricks, E. M., Michalak, A. J., Goldberg, A. R., Humala, N., Dovas, A., Rai, G., McKhann, G. M., Slesinger, P. A., Canoll, P., & Schevon, C. (2025). A selective small-molecule agonist of G protein-gated inwardly-rectifying potassium channels reduces epileptiform activity in mouse models of tumor-associated and provoked seizures. Neuropharmacology, 265, 110259. https://doi.org/10.1016/j.neuropharm.2024.110259
Authors:
Robert A Rifkin
Xiaoping Wu
Brianna Pereira
Brian Ja Gill
Edward M Merricks
Andrew J Michalak
Alexander R Goldberg
Nelson Humala
Athanassios Dovas
Ganesha Rai
Guy M McKhann
Paul A Slesinger
Peter Canoll
Catherine Schevon
Affiliated Authors:
Robert A Rifkin
Xiaoping Wu
Brianna Pereira
Brian Ja Gill
Edward M Merricks
Alexander R Goldberg
Nelson Humala
Athanassios Dovas
Guy M McKhann
Peter Canoll
Catherine Schevon
Author Keywords:
girk
giga1
gaba b receptor
glioma
antiseizure medication
gaba<sub>b</sub> receptor
gaba<sub>b</sub> receptor
gaba(b) receptor
Publication Type:
Article
Unique ID:
10.1016/j.neuropharm.2024.110259
PMID:
Publication Date:
Data Source:
PubMed

Record Created: