Inactivation of cellular retinol-binding protein 1 protects against bis-retinoid accumulation and light-induced retinal degeneration in mice

Widjaja-Adhi, M. A. K., Swigris, J., Plau, J., Chung, C., Walczak-Szeffer, A., Jastrzebska, B., Blaner, W. S., & Golczak, M. (2025). Inactivation of cellular retinol-binding protein 1 protects against bis-retinoid accumulation and light-induced retinal degeneration in mice. Journal of Biological Chemistry, 301(9), 110538. https://doi.org/10.1016/j.jbc.2025.110538
Authors:
Made Airanthi K Widjaja-Adhi
Jaclyn Swigris
Jacqueline Plau
Chloe Chung
Anna Walczak-Szeffer
Beata Jastrzebska
William S Blaner
Marcin Golczak
Affiliated Authors:
William S Blaner
Author Keywords:
a2e
rbp1
retinal degeneration
retinoids
retinol-binding protein 1
visual cycle
cannabidiol
ketamine
100-w zhma ip66 diode lamps
abi steponeplus qrt pcr instrument
agilent 1200 hplc system
agilent zorbax sil
celeris rodent erg system
diagnosys espion v6 software
envisu r2210 uhr 120v
excel software
hra spectralis
leica cm1950 cryostat
ltq velos linear ion trap mass spectrometer
nanodrop spectrophotometer
neewer tt560 photographic flash unit
odyssey xf imaging system
olympus fv1200 laser scanning microscope
origin 2024
rneasy mini kit
rotary speedvac
xbridge beh c4 reverse phase hplc column
zeiss axioscan.z1
zen blue software
biochemistry
eye protection
ophthalmology
cellular retinol-binding proteins
light-induced
retinal degenerations
retinol-binding protein
mammals
bis retinoid
cellular retinol binding protein 1
retinoid
unclassified drug
animal experiment
animal model
animal tissue
article
autofluorescence
confocal laser scanning microscopy
controlled study
drug accumulation
electroretinography
gene expression
genotype
high performance liquid chromatography
histology
immunohistochemistry
light induced retinal degeneration
liquid chromatography-mass spectrometry
mouse
nonhuman
optical coherence tomography
phenotype
photoreceptor
protein expression
real time polymerase chain reaction
retina degeneration
retina injury
retinal pigment epithelium
reverse transcription polymerase chain reaction
rna extraction
rna isolation
scanning laser ophthalmoscopy
ultraviolet visible spectroscopy
western blotting
Publication Type:
Article
Unique ID:
10.1016/j.jbc.2025.110538
PMID:
Publication Date:
Data Source:
PubMed

Record Created: