Systemic T-cell activation and IFN-γ activity in indeterminate severe hepatitis are reminiscent of hemophagocytic lymphohistiocytosis: Implications for T-cell- and IFN-γ-directed therapies

Nguyen, T. H., Satwani, P., Kumar, D., Kapoor, U., Malik, S., Prince, C., Montminy, T., Smiley, K., Martinez, M., Goldner, D., Marsh, R., Remotti, H. E., Fazlollahi, L., Rytting, H. B., Romero, R., & Chandrakasan, S. (2024). Systemic T-cell activation and IFN-γ activity in indeterminate severe hepatitis are reminiscent of hemophagocytic lymphohistiocytosis: Implications for T-cell– and IFN-γ–directed therapies. Journal of Allergy and Clinical Immunology. https://doi.org/10.1016/j.jaci.2024.08.029
Authors:
Thinh H Nguyen
Prakash Satwani
Deepak Kumar
Urvi Kapoor
Sakshi Malik
Chengyu Prince
Taylor Montminy
Kristi Smiley
Mercedes Martinez
Dana Goldner
Rebecca Marsh
Helen E Remotti
Ladan Fazlollahi
Heather B Rytting
Rene Romero
Shanmuganathan Chandrakasan
Affiliated Authors:
Prakash Satwani
Urvi Kapoor
Mercedes Martinez
Dana Goldner
Helen E Remotti
Ladan Fazlollahi
Columbia Affiliation:
Author Keywords:
indeterminate severe hepatitis
hemophagocytic lymphohistiocytosis
indeterminate pediatric acute liver failure
cd8+t-cell activation
soluble interleukin-2 receptor
ferritin
posthepatitis aplastic anemia
cd8<sup>+</sup> t-cell activation
cd8<sup>+</sup> t-cell activation
cd8(+) t-cell activation
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Publication Type:
Article
Unique ID:
10.1016/j.jaci.2024.08.029
PMID:
39278359
DOI:
10.1016/j.jaci.2024.08.029
Journal:
Journal of Allergy and Clinical Immunology
Publication Date:
Data Source:
PubMed
Source Link:
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Record Created: