Coenzyme Q10 deficiency disrupts lipid metabolism by altering cholesterol homeostasis in neurons

Pesini, A., Barriocanal-Casado, E., Compagnoni, G. M., Hidalgo-Gutierrez, A., Yanez, G., Bakkali, M., Chhonker, Y. S., Kleiner, G., Larrea, D., Tadesse, S., Lopez, L. C., Murry, D. J., Di Fonzo, A., Area-Gomez, E., & Quinzii, C. M. (2025). Coenzyme Q10 deficiency disrupts lipid metabolism by altering cholesterol homeostasis in neurons. Free Radical Biology and Medicine, 229, 441–457. https://doi.org/10.1016/j.freeradbiomed.2025.01.009
Authors:
Alba Pesini
Eliana Barriocanal‐Casado
Giacomo Monzio Compagnoni
Agustín Hidalgo‐Gutiérrez
Giussepe Yanez
Mohammed Bakkali
Yashpal S. Chhonker
Giulio Kleiner
Delfina Larrea
Saba Tadesse
Luís C. López
Daryl J. Murry
Alessio Di Fonzo
Estela Area-Gomez
Catarina M. Quinzii
Affiliated Authors:
Alba Pesini
Eliana Barriocanal‐Casado
Agustín Hidalgo‐Gutiérrez
Giussepe Yanez
Giulio Kleiner
Delfina Larrea
Saba Tadesse
Catarina M. Quinzii
Columbia Affiliation:
Subjects:
Ubiquinone (MeSH)
Neurons (MeSH)
Cholesterol (MeSH)
Homeostasis (MeSH)
Lipid Metabolism (MeSH)
Ataxia (MeSH)
Mevalonic Acid (MeSH)
Mitochondrial Diseases (MeSH)
Muscle Weakness (MeSH)
Metabolism and Functions of Coenzyme Q (OpenAlex Topic)
Role of Lipoic Acid in Metabolism and Health (OpenAlex Topic)
Organic Chemistry Cycloaddition Reactions (OpenAlex Topic)
Author Keywords:
cholesterol
coq2
lipids
pdss2
coenzyme q10
coenzyme q<sub>10</sub>
coenzyme q(10)
coenzyme q<sub>10</sub>
elink
Publication Type:
Article
Unique ID:
10.1016/j.freeradbiomed.2025.01.009
PMID:
39788391
DOI:
10.1016/j.freeradbiomed.2025.01.009
Journal:
Free Radical Biology and Medicine
Publication Date:
Data Source:
OpenAlex
Source Link:
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Record Created: