Frizzled5 controls murine intestinal epithelial cell plasticity through organization of chromatin accessibility

Deng, L., He, X. C., Chen, S., Zhang, N., Deng, F., Scott, A., He, Y., Tsuchiya, D., Smith, S. E., Epp, M., Malloy, S., Liu, F., Hembree, M., Mu, Q., Haug, J. S., Malagola, E., Hassan, H., Petentler, K., Egidy, R., … Li, L. (2024). Frizzled5 controls murine intestinal epithelial cell plasticity through organization of chromatin accessibility. Developmental Cell. https://doi.org/10.1016/j.devcel.2024.10.021
Authors:
Lu Deng
Xi C He
Shiyuan Chen
Ning Zhang
Fengyan Deng
Allison Scott
Yanfeng He
Dai Tsuchiya
Sarah E Smith
Michael Epp
Seth Malloy
Fang Liu
Mark Hembree
Qinghui Mu
Jeffrey S Haug
Ermanno Malagola
Huzaifa Hassan
Kaitlyn Petentler
Rhonda Egidy
Lucinda Maddera
Jonathon Russell
Yan Wang
Hua Li
Chongbei Zhao
Anoja Perera
Timothy C Wang
Calvin J Kuo
Linheng Li
Affiliated Authors:
Ermanno Malagola
Timothy C Wang
Columbia Affiliation:
Author Keywords:
chromatin accessibility
fzd5
intestinal stem cell
plasticity
single-cell transcriptome and epigenome
wnt pathway
chromatin
frizzled receptors
fzd5 protein, mouse
lgr5 protein, mouse
receptors, g-protein-coupled
protein derivative
protein frizzled5
transcriptome
unclassified drug
frizzled protein
g protein coupled receptor
animal cell
article
cell fate
cell plasticity
chromatin immunoprecipitation sequencing
controlled study
epigenome
gene expression
homeostasis
intestine epithelium
intestine epithelium cell
lgr5+ stem cell line
mouse
nonhuman
single cell rna seq
small intestine crypt
wnt signaling
animal
cell differentiation
cell lineage
cytology
epithelium cell
genetics
intestine mucosa
metabolism
stem cell
animals
epithelial cells
intestinal mucosa
mice
stem cells
wnt signaling pathway
Grants:
R01DK115728 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)
U01DK085527 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)
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Publication Type:
Article
Unique ID:
10.1016/j.devcel.2024.10.021
PMID:
39579769
DOI:
10.1016/j.devcel.2024.10.021
Journal:
Developmental Cell
Publication Date:
Data Source:
PubMed
Source Link:
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