Patient-derived monoclonal LGI1 autoantibodies elicit seizures, behavioral changes and brain MRI abnormalities in rodent models

Upadhya, M., Stumpf, A., O’Brien-Cairney, J., Gómez, C. C., Döring, J., Hoffmann, J., Mueller, S., Fukata, Y., van Hoof, S., Dhangar, D., Wilson, M. A., Atwal, A., Rosch, R., Woodhall, G., Boehm-Sturm, P., Fukata, M., Kreye, J., Schmitz, D., Wright, S. K., … Prüss, H. (2025). Patient-derived monoclonal LGI1 autoantibodies elicit seizures, behavioral changes and brain MRI abnormalities in rodent models. Brain, Behavior, and Immunity, 126, 342–355. https://doi.org/10.1016/j.bbi.2025.02.019
Authors:
Manoj Upadhya
Jack O'Brien-Cairney
Divya Dhangar
Max A. Wilson
Arunvir Atwal
Gavin Woodhall
Sukhvir K. Wright
Alexander Stumpf
Cesar Cordero Gomez
Julius Hoffmann
Susanne Mueller
Scott van Hoof
Philipp Boehm-Sturm
Jakob Kreye
Dietmar Schmitz
Hans-Christian Kornau
Harald Pruess
Jan Doering
Yuko Fukata
Masaki Fukata
Richard Rosch
Affiliated Authors:
Richard Rosch
Author Keywords:
limbic encephalitis
lgi1
human monoclonal antibody
animal model
seizure
Publication Type:
Article
Unique ID:
10.1016/j.bbi.2025.02.019
PMID:
Publication Date:
Data Source:
Web of Science

Record Created: