CIROZ is dispensable in ancestral vertebrates but essential for left-right patterning in humans

Szenker-Ravi, E., Ott, T., Yusof, A., Chopra, M., Khatoo, M., Pak, B., Xuan Goh, W., Beckers, A., Brady, A. F., Ewans, L. J., Djaziri, N., Almontashiri, N. A. M., Alghamdi, M. A., Alharby, E., Dasouki, M., Romo, L., Tan, W.-H., Maddirevula, S., Alkuraya, F. S., … Reversade, B. (2025). CIROZ is dispensable in ancestral vertebrates but essential for left-right patterning in humans. The American Journal of Human Genetics. https://doi.org/10.1016/j.ajhg.2024.12.006
Authors:
Emmanuelle Szenker-Ravi
Tim Ott
Amirah Yusof
Maya Chopra
Muznah Khatoo
Beatrice Pak
Wei Xuan Goh
Anja Beckers
Angela F Brady
Lisa J Ewans
Nabila Djaziri
Naif A M Almontashiri
Malak Ali Alghamdi
Essa Alharby
Majed Dasouki
Lindsay Romo
Wen-Hann Tan
Sateesh Maddirevula
Fowzan S Alkuraya
Jessica L Giordano
Anna Alkelai
Ronald J Wapner
Karen Stals
Majid Alfadhel
Abdulrahman Faiz Alswaid
Susanne Bogusch
Anna Schafer-Kosulya
Sebastian Vogel
Philipp Vick
Axel Schweickert
Matthew Wakeling
Anne Moreau de Bellaing
Aisha M Alshamsi
Damien Sanlaville
Hamdi Mbarek
Chadi Saad
Sian Ellard
Frank Eisenhaber
Kornelia Tripolszki
Christian Beetz
Peter Bauer
Achim Gossler
Birgit Eisenhaber
Martin Blum
Patrice Bouvagnet
Aida Bertoli-Avella
Jeanne Amiel
Christopher T Gordon
Bruno Reversade
Affiliated Authors:
Jessica L Giordano
Anna Alkelai
Ronald J Wapner
Columbia Affiliation:
Author Keywords:
c1orf127
cirop
ciroz
dand5
evo-devo
gene loss
heterotaxy
laterality
left-right organizer
mmp21
motile cilia
pkd1l1
pseudogenization
zp-n
zp2
elink
Publication Type:
Article
Unique ID:
10.1016/j.ajhg.2024.12.006
PMID:
39753129
DOI:
10.1016/j.ajhg.2024.12.006
Journal:
American Journal of Human Genetics
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record
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Record Created: