Inflation of polygenic risk scores caused by sample overlap and relatedness: Examples of a major risk of bias

Ellis, C. A., Oliver, K. L., Harris, R. V., Ottman, R., Scheffer, I. E., Mefford, H. C., Epstein, M. P., Berkovic, S. F., & Bahlo, M. (2024). Inflation of polygenic risk scores caused by sample overlap and relatedness: Examples of a major risk of bias. The American Journal of Human Genetics, 111(9), 1805–1809. https://doi.org/10.1016/j.ajhg.2024.07.014

Authors:

Colin A Ellis

Karen L Oliver

Rebekah V Harris

Ruth Ottman

Ingrid E Scheffer

Heather C Mefford

Michael P Epstein

Samuel F Berkovic

Melanie Bahlo

Affiliated Authors:

Ruth Ottman