Polygenic transcriptome risk scores for COPD and lung function improve cross-ethnic portability of prediction in the NHLBI TOPMed program

Hu, X., Qiao, D., Kim, W., Moll, M., Balte, P. P., Lange, L. A., Bartz, T. M., Kumar, R., Li, X., Yu, B., Cade, B. E., Laurie, C. A., Sofer, T., Ruczinski, I., Nickerson, D. A., Muzny, D. M., Metcalf, G. A., Doddapaneni, H., Gabriel, S., … Manichaikul, A. (2022). Polygenic transcriptome risk scores for COPD and lung function improve cross-ethnic portability of prediction in the NHLBI TOPMed program. The American Journal of Human Genetics, 109(5), 857–870. https://doi.org/10.1016/j.ajhg.2022.03.007
Authors:
Xiaowei Hu
Dandi Qiao
Wonji Kim
Matthew Moll
Pallavi P. Balte
Leslie A. Lange
Traci M. Bartz
Rajesh Kumar
Xingnan Li
Bing Yu
Brian E. Cade
Cecelia A. Laurie
Tamar Sofer
Ingo Ruczinski
Deborah A. Nickerson
Donna M. Muzny
Ginger A. Metcalf
Harshavardhan Doddapaneni
Stacy Gabriel
Namrata Gupta
Shannon Dugan-Perez
L. Adrienne Cupples
Laura R. Loehr
Deepti Jain
Jerome I. Rotter
James G. Wilson
Bruce M. Psaty
Myriam Fornage
Alanna C. Morrison
Ramachandran S. Vasan
George Washko
Stephen S. Rich
George T. O'Connor
Eugene Bleecker
Robert C. Kaplan
Ravi Kalhan
Susan Redline
Sina A. Gharib
Deborah Meyers
Victor Ortega
Josée Dupuis
Stephanie J. London
Tuuli Lappalainen
Elizabeth C. Oelsner
Edwin K. Silverman
R. Graham Barr
Timothy A. Thornton
Heather E. Wheeler
Michael H. Cho
Hae Kyung Im
Ani Manichaikul
Affiliated Authors:
Pallavi P. Balte
Tuuli Lappalainen
Elizabeth C. Oelsner
R. Graham Barr
Columbia Affiliation:
Subjects:
Pulmonary Disease, Chronic Obstructive (MeSH)
Transcriptome (MeSH)
Standardisation and Management of COPD (OpenAlex Topic)
Genomic Studies and Association Analyses (OpenAlex Topic)
Effectiveness of General Health Check Programs (OpenAlex Topic)
Author Keywords:
cross-ethnic portability
gene expression
integrative analysis
polygenic transcriptome risk score
pulmonary disease
risk prediction
elink
Publication Type:
Article
Unique ID:
10.1016/j.ajhg.2022.03.007
PMID:
35385699
DOI:
10.1016/j.ajhg.2022.03.007
Journal:
American Journal of Human Genetics
Publication Date:
Data Source:
Scopus
Source Link:
View Scopus Record
View Web of Science Record
View OpenAlex Record
View PubMed Record

Record Created: