EPHX1 mutations cause a lipoatrophic diabetes syndrome due to impaired epoxide hydrolysis and increased cellular senescence

Gautheron, J., Morisseau, C., Chung, W. K., Zammouri, J., Auclair, M., Baujat, G., Capel, E., Moulin, C., Wang, Y., Yang, J., Hammock, B. D., Cerame, B., Phan, F., Fève, B., Vigouroux, C., Andreelli, F., & Jeru, I. (2021). EPHX1 mutations cause a lipoatrophic diabetes syndrome due to impaired epoxide hydrolysis and increased cellular senescence. ELife, 10. CLOCKSS. https://doi.org/10.7554/elife.68445

Authors:

Jeremie Gautheron

Christophe Morisseau

Wendy K Chung

Jamila Zammouri

Martine Auclair

Genevieve Baujat

Emilie Capel

Celia Moulin

Yuxin Wang

Jun Yang

Bruce D Hammock

Barbara Cerame

Franck Phan

Bruno Fève

Corinne Vigouroux

Fabrizio Andreelli

Isabelle Jeru

Affiliated Authors:

Wendy K Chung

Columbia Affiliation:

Vagelos College of Physicians and Surgeons
- Department of Pediatrics
- Department of Medicine

Subjects:

Metabolism and Function of Arachidonic Acid Derivatives (OpenAlex Topic)

Role of Lipoic Acid in Metabolism and Health (OpenAlex Topic)

Management of Primary Aldosteronism (OpenAlex Topic)

Cellular Senescence (MeSH)

Diabetes Mellitus, Lipoatrophic (MeSH)

Epoxide Hydrolases (MeSH)

Epoxy Compounds (MeSH)

Author Keywords:

ephx1

adipocyte

cellular senescence

diabetes

epoxide hydrolase

genetics

genomics

human

medicine

Publication Type:

Article

Unique ID:

10.7554/elife.68445

PMID:

DOI:

10.7554/elife.68445

Journal:

Publication Date:

2021-08-04

Data Source:

PubMed

Source Link:

View PubMed Record

View Web of Science Record

View OpenAlex Record

Record Created:

Tuesday, June 24, 2025 - 11:08