Determinants of SARS-CoV-2 entry and replication in airway mucosal tissue and susceptibility in smokers

Nakayama, T., Lee, I. T., Jiang, S., Matter, M. S., Yan, C. H., Overdevest, J. B., Wu, C.-T., Goltsev, Y., Shih, L.-C., Liao, C.-K., Zhu, B., Bai, Y., Lidsky, P., Xiao, Y., Zarabanda, D., Yang, A., Easwaran, M., Schürch, C. M., Chu, P., … Nayak, J. V. (2021). Determinants of SARS-CoV-2 entry and replication in airway mucosal tissue and susceptibility in smokers. Cell Reports Medicine, 2(10), 100421. https://doi.org/10.1016/j.xcrm.2021.100421
Authors:
Tsuguhisa Nakayama
Ivan T Lee
Sizun Jiang
Matthias S Matter
Carol H Yan
Jonathan B Overdevest
Chien-Ting Wu
Yury Goltsev
Liang-Chun Shih
Chun-Kang Liao
Bokai Zhu
Yunhao Bai
Peter Lidsky
Yinghong Xiao
David Zarabanda
Angela Yang
Meena Easwaran
Christian M Schürch
Pauline Chu
Han Chen
Anna K Stalder
David R McIlwain
Nicole A Borchard
Phillip A Gall
Sachi S Dholakia
Wei Le
Le Xu
Chih-Jaan Tai
Te-Huei Yeh
Elizabeth Erickson-Direnzo
Jason M Duran
Kirsten D Mertz
Peter H Hwang
Jasmin D Haslbauer
Peter K Jackson
Thomas Menter
Raul Andino
Peter D Canoll
Adam S DeConde
Zara M Patel
Alexandar Tzankov
Garry P Nolan
Jayakar V Nayak
Affiliated Authors:
Jonathan B Overdevest
Peter D Canoll
Columbia Affiliation:
Subjects:
Angiotensin-Converting Enzyme 2 (MeSH)
COVID-19 (MeSH)
Respiratory Mucosa (MeSH)
Serine Endopeptidases (MeSH)
Smokers (MeSH)
Viral Tropism (MeSH)
Author Keywords:
ace2
ciliated epithelial cell
covid-19
ifn-β1
nasal cavity
sars-cov-2
smoking
tmprss2
trachea
upper airway
elink
Publication Type:
Article
Unique ID:
10.1016/j.xcrm.2021.100421
PMID:
34604819
DOI:
10.1016/j.xcrm.2021.100421
Journal:
Cell Reports Medicine
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record
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Record Created: