Risk factors affecting polygenic score performance across diverse cohorts

Hui, D., Dudek, S., Kiryluk, K., Walunas, T. L., Kullo, I. J., Wei, W.-Q., Tiwari, H., Peterson, J. F., Chung, W. K., Davis, B. H., Khan, A., Kottyan, L. C., Limdi, N. A., Feng, Q., Puckelwartz, M. J., Weng, C., Smith, J. L., Karlson, E. W., … Ritchie, M. D. (2025). Risk factors affecting polygenic score performance across diverse cohorts. ELife, 12. CLOCKSS. https://doi.org/10.7554/elife.88149
Authors:
Daniel Hui
Scott Dudek
Krzysztof Kiryluk
Theresa L Walunas
Iftikhar J Kullo
Wei-Qi Wei
Hemant Tiwari
Josh F Peterson
Wendy K Chung
Brittney H Davis
Atlas Khan
Leah C Kottyan
Nita A Limdi
Qiping Feng
Megan J Puckelwartz
Chunhua Weng
Johanna L Smith
Elizabeth W Karlson
Gail P Jarvik
Marylyn D Ritchie
Affiliated Authors:
Krzysztof Kiryluk
Wendy K Chung
Atlas Khan
Chunhua Weng
Columbia Affiliation:
Subjects:
Multifactorial Inheritance (MeSH)
Body Mass Index (MeSH)
Genomic Studies and Association Analyses (OpenAlex Topic)
Genomic Selection in Plant and Animal Breeding (OpenAlex Topic)
Genetic Architecture of Quantitative Traits (OpenAlex Topic)
Author Keywords:
body mass index
computational biology
genetics
gene–environment
genomics
gwas
human
polygenic scores
systems biology
elink
Publication Type:
Article
Unique ID:
10.7554/elife.88149
PMID:
39851248
DOI:
10.7554/elife.88149
Journal:
eLife
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record
View OpenAlex Record
View Scopus Record
View Web of Science Record

Record Created: